Domain

Cyanovirin-N (IPR011058)

Short name: Cyanovirin-N

Domain relationships

None.

Description

Cyanovirin-N (CV-N) is an 11kDa protein from the cyanobacterium Nostoc ellipsosporum that displays virucidal activity against several viruses, including human immunodeficiency virus (AIDS). The virucidal activity of CV-N is mediated through specific high-affinity interactions with the viral surface envelope glycoproteins gp120 and gp41, as well as to high-mannose oligosaccharides found on the HIV envelope [PMID: 12678493]. In addition, CV-N is active against rhinoviruses, human parainfluenza virus, respiratory syncytial virus, and enteric viruses. The virucidal activity of CV-N against influenza virus is directed towards viral haemagglutinin [PMID: 12878514].

The CV-N domain is evolutionarily conserved and occurs as a protein module in eukaryotes [PMID: 16003744]. CV-N has a complex fold composed of a duplication of a tandem repeat of two homologous motifs comprising three-stranded beta-sheet and beta-hairpins [PMID: 12110688].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
Pfam