- Course overview
- Search within this course
- Introduction to EMBL-EBI resources
- Introduction to programmatic access
- EBI Search, programmatically
- Europe PMC, programmatically
- Ensembl, programmatically
- UniProt, programmatically
- InterPro, programmatically
- PDBe, programmatically
- ChEMBL and UniChem, programmatically
- Sequence analysis tools, programmatically
- EVA, programmatically
- MGnify, programmatically
- Summary
- Your feedback
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Open Targets Genetics
Open Targets Genetics is a tool highlighting variant-centric statistical evidence to allow both prioritisation of candidate causal variants at trait-associated loci and identification of potential drug targets. It allows users to explore data related to genes, traits, or variants.
This platform integrates functional and biological data, including genetic associations from the literature, UK Biobank, FinnGen, and quantitative trait loci (eQTLs, pQTLs, and sQTLs). We link variants to their proximal and distal target gene(s), to prioritise ‘causal’ genes at a trait-associated locus. Top-prioritised genes from our Locus-to-Gene scoring algorithm feed into the Open Targets Platform as evidence for target-disease associations.
Open Targets Genetics is accessible via:
- A web interface, in which individual data tables and visualisations can be downloaded for further analysis
- The GraphQL API, accessible with the programming language of your choice, or API playground with built-in documentation, which is useful for constructing and testing queries
- The Google BigQuery instance — project open-targets-genetics:genetics — which supports SQL-like queries. Open Targets Genetics data is available as a Google Cloud public dataset.
- The FTP data downloads, to explore specific datasets and integrate them into your own pipelines.
For further information and help
- Visit the documentation (Open Targets Platform, including our data access documentation with sample scripts; Open Targets Genetics, including data access documentation)
- Watch the full introductory webinar to the Open Targets Platform, or the introduction to the GraphQL API
- Take a look at the source code on GitHub
- Join the Open Targets Community for FAQs, user questions, and example code
- Read the Open Targets Blog for in-depth dives into the software underpinning the Platform
If you’d like regular updates: we are on Twitter @opentargets, on LinkedIn, we post video walkthroughs and explanations on YouTube and we have a monthly newsletter.