2,6-dioxo-6-phenylhexa-3-enoate hydrolase (M-CSA:437)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this chain

The residue id shown is the one in the PDB sequence. This may be different from the resid given by the author of the PDB file.

PDB sequences homologous to 1c4x

Reference PDB chains/ identical chains Homologous PDB chains Asn109(110)A Trp264(265)A Asp235(236)A Ser110(111)A His263(264)A Gly40(41)A (main-N) Met111(112)A (main-N) Arg186(187)A
1c4x(A)
PfamFunTree
5jzb(B,A)
PfamFunTree
Asn107 Trp264 Asp235 Ser108 His263 Gly42 Leu109 Arg186
1c4x(A)
PfamFunTree
2pu7(A)
PfamFunTree
2puj(A)
PfamFunTree
Asn111 Trp266 Asp237 Ala112 Ala265 Gly45 Met113 Arg190
1c4x(A)
PfamFunTree
2rht(A)
PfamFunTree
2ri6(A)
PfamFunTree
2rhw(A)
PfamFunTree
Asn108 Trp263 Asp234 Ala109 His262 Gly42 Met110 Arg187
1c4x(A)
PfamFunTree
1j1i(A)
PfamFunTree
Asn113 Trp262 Asp233 Ser114 His261 Gly48 Met115 Arg185
1c4x(A)
PfamFunTree
2r11(B,D,A,C)
PfamFunTree
Leu141 Val287 Glu257 Ser142 His286 not aligned Leu143 not aligned
1c4x(A)
PfamFunTree
2puh(A)
PfamFunTree
Asn111 Trp266 Asp237 Ala112 His265 Gly45 Met113 Arg190
1c4x(A)
PfamFunTree
4psu(A)
PfamFunTree
His113 Leu271 Asp242 Ser114 His270 not aligned Ala115 Arg176
1c4x(A)
PfamFunTree
3v1l(A)
PfamFunTree
3v1m(A)
PfamFunTree
Asn111 Trp266 Asp237 Ala112 Gln265 Gly45 Met113 Arg190
1c4x(A)
PfamFunTree
2pu5(B,A)
PfamFunTree
2og1(B,A)
PfamFunTree
Asn111 Trp266 Asp237 Ser112 His265 Gly45 Met113 Arg190
1c4x(A)
PfamFunTree
4ccw(A)
PfamFunTree
Leu128 Val274 Glu244 Ser129 His273 not aligned Leu130 not aligned
1c4x(A)
PfamFunTree
2vf2(B,A)
PfamFunTree
Asn133 Trp290 Asp261 Ser134 His289 Gly68 Leu135 Arg212
1c4x(A)
PfamFunTree
4ns4(A)
PfamFunTree
Asn141 Val293 Asp264 Ser142 His292 not aligned Met143 not aligned
1c4x(A)
PfamFunTree
5jz9(B,A)
PfamFunTree
5jzs(B,A)
PfamFunTree
Asn107 Trp264 Asp235 Ser108 His263 Gly42 Leu109 Arg186
1c4x(A)
PfamFunTree
4lxg(A)
PfamFunTree
Asn104 Trp256 Asp227 Ser105 His255 Gly37 Met106 Arg180
1c4x(A)
PfamFunTree
1c4x(A)
PfamFunTree
x x x x x x x x
1c4x(A)
PfamFunTree
4lxh(A)
PfamFunTree
4lyd(A)
PfamFunTree
4lye(A)
PfamFunTree
4lxi(A)
PfamFunTree
Asn104 Trp256 Asp227 Ala105 His255 Gly37 Met106 Arg180
1c4x(A)
PfamFunTree
4i3f(A)
PfamFunTree
Asn124 Trp280 Asp251 Ser125 His279 Gly56 Met126 Arg201
1c4x(A)
PfamFunTree
1uka(A)
PfamFunTree
1iuo(A)
PfamFunTree
1iun(B,A)
PfamFunTree
1uk7(A)
PfamFunTree
1ukb(A)
PfamFunTree
1uk6(A)
PfamFunTree
1iup(A)
PfamFunTree
1uk9(A)
PfamFunTree
1uk8(A)
PfamFunTree
Asn102 Trp253 Asp224 Ala103 His252 Gly37 Phe104 Arg174
1c4x(A)
PfamFunTree
2d0d(A)
PfamFunTree
Asn102 Trp253 Asp224 Ser103 His252 Gly37 Phe104 Arg174
1c4x(A)
PfamFunTree
4nvr(C,B,A,D)
PfamFunTree
His118 Ser286 Gly257 Asp119 His285 not aligned Arg120 Phe185
1c4x(A)
PfamFunTree
3v1k(B,A)
PfamFunTree
3v1n(A)
PfamFunTree
Asn111 Trp266 Asp237 Ser112 Gln265 Gly45 Met113 Arg190
1c4x(A)
PfamFunTree
1u2e(B,A,D,C)
PfamFunTree
Asn114 Trp269 Asp240 Ser115 His268 Gly48 Met116 Arg193
1c4x(A)
PfamFunTree
5cw2(C,B,A,D)
PfamFunTree
His106 Trp302 Asp272 Asp107 His301 not aligned Trp108 Arg177
1c4x(A)
PfamFunTree
2wuf(B,A)
PfamFunTree
2wug(B,A)
PfamFunTree
2wue(B,A)
PfamFunTree
2wud(B,A)
PfamFunTree
Asn113 Trp270 Asp241 Ala114 His269 Gly48 Leu115 Arg192
1c4x(A)
PfamFunTree
3qyj(B,A)
PfamFunTree
His103 Phe271 Gly242 Asp104 His270 not aligned Arg105 Tyr170
1c4x(A)
PfamFunTree
5ng7(B,A)
PfamFunTree
x x x x x x x x
1c4x(A)
PfamFunTree
6azd(A)
PfamFunTree
x x x x x x x x
1c4x(A)
PfamFunTree
6i8w(B,A)
PfamFunTree
x x x x x x x x