Ligand clusters for UniProt code Q9NWT6

Ligand clusters for Q9NWT6: Hypoxia-inducible factor 1-alpha inhibitor from Homo sapiens

		Top 6 (of 14) ligand clusters Cluster 1. 27 ligand types 126 ligands Cluster 2. 3 ligand types 41 ligands Cluster 3. 2 ligand types 33 ligands Cluster 4. 2 ligand types 21 ligands Cluster 5. 2 ligand types 6 ligands Cluster 6. 2 ligand types 6 ligands
Representative protein: 2xumA

Structures

PDB		Schematic diagram
2xumA
2yc0A
2ydeA
6hc8A
6ha6A
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Cluster 1 contains 27 ligand types (of which only 20 are listed. Click for all)

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Ligand		Description
_Zn		1. Metal: _ZN × 21 PDB codes: 1h2m(A), 2xum(A), 3d8c(A), 3od4(A), 4ai8(A), 4b7e(A), 4b7k(A), 4jaa(A), 4nr1(A), 5jwl(A), 5jwp(A), 5op6(A), 5op8(A), 5opc(A), 6h9j(A), 6ha6(A), 6hc8(A), 6hkp(A), 6hl5(A), 6hl6(A), 6ruj(A).
		2. Ligand: GOL × 14 glycerin Glycerol PDB codes: 2ilm(A), 2w0x(A), 2yc0(A), 2yde(A), 3od4(A), 4ai8(A), 4b7e(A), 4bio(A), 5op6(A), 5op8(A), 5opc(A), 6hl5(A).
_Fe		3. Metal: _FE × 5 PDB codes: 2cgn(A), 2cgo(A), 2yde(A), 4bio(A), 4z2w(A).
		4. Ligand: CQL × 1 clioquinol 5-Chloro-7-Iodoquinolin-8-Ol PDB code: 3kcx(A).
		5. Ligand: SIN × 1 succinic acid Succinic acid PDB code: 2cgn(A).
		6. Ligand: SO4 × 18 Sulfate ion PDB codes: 1h2n(A), 1iz3(A), 1yci(A), 2cgn(A), 2cgo(A), 2ilm(A), 2w0x(A), 2wa4(A), 2yde(A), 3kcx(A), 3kcy(A), 3od4(A), 4ai8(A), 4bio(A), 4z2w(A), 5opc(A), 6ha6(A), 6hkp(A).
Fe2		7. Metal: FE2 × 17 PDB codes: 1h2k(A), 1h2l(A), 1h2n(A), 1mze(A), 1mzf(A), 1yci(A), 2ilm(A), 2w0x(A), 2wa3(A), 2wa4(A), 2y0i(A), 2yc0(A), 3kcx(A), 3kcy(A), 3p3n(A), 3p3p(A), 5jwk(A).
		8. Ligand: OGA × 14 N-Oxalylglycine PDB codes: 1h2k(A), 1h2m(A), 2xum(A), 4b7e(A), 4b7k(A), 4jaa(A), 4nr1(A), 6h9j(A), 6ha6(A), 6hc8(A), 6hkp(A), 6hl5(A), 6hl6(A), 6ruj(A).
		9. Ligand: AKG × 12 2-Oxoglutaric acid PDB codes: 1h2l(A), 1h2n(A), 1mzf(A), 2ilm(A), 2y0i(A), 3d8c(A), 3p3n(A), 3p3p(A), 4z2w(A), 5jwk(A), 5jwl(A), 5jwp(A).
		10. Ligand: PEG × 3 Di(hydroxyethyl)ether PDB codes: 4z2w(A), 5jwk(A), 5jwl(A).
		11. Ligand: 069 × 2 N,3-Dihydroxybenzamide PDB codes: 2wa4(A),
		12. Ligand: 8XQ × 2 8-Hydroxyquinoline-5-Carboxylic acid PDB codes: 3od4(A), 4bio(A).
		13. Ligand: S2G × 2 (2s)-2-Hydroxypentanedioic acid PDB codes: 2yde(A),
		14. Ligand: 2HG × 1 (2r)-2-Hydroxypentanedioic acid PDB code: 2yc0(A).
		15. Ligand: A0W × 1 2-[[1,3-Dicyclohexyl-4-Oxidanyl-2,6-Bis(oxidanylidene) pyrimidin-5-Yl]carbonylamino]ethanoic acid PDB code: 5op6(A).
		16. Ligand: A1H × 1 2-(6-Morpholin-4-Ylpyrimidin-4-Yl)-4-(1,2,3-Triazol-1- Yl)-1~{h}-Pyrazol-3-One PDB code: 5op8(A).
		17. Ligand: A1Z × 1 Vadadustat PDB code: 5opc(A).
		18. Ligand: A29 × 1 2-(3-Hydroxyphenyl)-2-Oxo-Ethanoic acid PDB code: 2wa3(A).
		19. Ligand: ARG-LEU-LEU-GLU-ALA-SER-ALA-ASP-ALA-ASN × 1 PDB code: 3p3n(A).
		20. Ligand: BCT × 1 Bicarbonate ion PDB code: 2ilm(A).
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Cluster 2 contains 3 ligand types

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Ligand		Description
		1. Ligand: GOL × 10 glycerin Glycerol PDB codes: 2y0i(A), 2yc0(A), 3kcx(A), 3p3n(A), 3p3p(A), 4ai8(A), 4b7e(A), 5opc(A), 6hc8(A).
		2. Ligand: SO4 × 30 Sulfate ion PDB codes: 2cgn(A), 2cgo(A), 2xum(A), 2y0i(A), 2yc0(A), 2yde(A), 3p3n(A), 4ai8(A), 4b7e(A), 4b7k(A), 4bio(A), 4jaa(A), 4nr1(A), 4z2w(A), 5jwk(A), 5jwl(A), 5jwp(A), 5op6(A), 5op8(A), 5opc(A), 6h9j(A), 6ha6(A), 6hkp(A), 6hl5(A), 6hl6(A), 6ruj(A).
		3. Ligand: NDF × 1 N-(Carboxycarbonyl)-D-Phenylalanine PDB code: 1yci(A).

Cluster 3 contains 2 ligand types

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Ligand		Description
		1. Ligand: GOL × 4 glycerin Glycerol PDB codes: 5opc(A), 6h9j(A), 6hl5(A), 6hl6(A).
		2. Ligand: SO4 × 29 Sulfate ion PDB codes: 1h2k(A), 1h2l(A), 1h2m(A), 1h2n(A), 1yci(A), 2cgn(A), 2cgo(A), 2w0x(A), 2xum(A), 2y0i(A), 2yc0(A), 2yde(A), 3d8c(A), 3od4(A), 3p3p(A), 4ai8(A), 4b7e(A), 4b7k(A), 4bio(A), 4nr1(A), 5jwp(A), 5opc(A), 6h9j(A), 6ha6(A), 6hkp(A), 6hl5(A), 6hl6(A), 6ruj(A).

Cluster 4 contains 2 ligand types

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Ligand		Description
		1. Ligand: GOL × 20 glycerin Glycerol PDB codes: 2y0i(A), 2yc0(A), 2yde(A), 3d8c(A), 3kcx(A), 3od4(A), 3p3n(A), 3p3p(A), 4ai8(A), 4bio(A), 5jwp(A), 5op8(A), 5opc(A), 6h9j(A), 6ha6(A), 6hc8(A), 6hkp(A), 6hl5(A), 6hl6(A).
		2. Ligand: SO4 × 1 Sulfate ion PDB code: 4b7e(A).

Cluster 5 contains 2 ligand types

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Ligand		Description
		1. Ligand: GOL × 2 glycerin Glycerol PDB codes: 4b7e(A), 6hl6(A).
		2. Ligand: SO4 × 4 Sulfate ion PDB codes: 2yc0(A), 6h9j(A), 6hkp(A), 6hl5(A).

Cluster 6 contains 2 ligand types

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 6ha6(A).
		2. Ligand: SO4 × 5 Sulfate ion PDB codes: 4b7k(A), 4z2w(A), 5op8(A), 5opc(A), 6hkp(A).