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Ligand clusters for UniProt code P68135

Ligand clusters for P68135: Actin, alpha skeletal muscle from Oryctolagus cuniculus

Top 6 (of 31) ligand clusters


Cluster 1. 37 ligand types 114 ligands		Cluster 2. 10 ligand types 29 ligands		Cluster 3. 10 ligand types 248 ligands		Cluster 4. 2 ligand types 2 ligands		Cluster 5. 5 ligand types 8 ligands		Cluster 6. 2 ligand types 2 ligands

Representative protein: 2y83O

Structures

PDB		Schematic diagram

2y83O
3m6gA
7c2fA
4b1wB
2v52B
		more ...

Cluster 1 contains 37 ligand types (of which only 20 are listed. Click for all)

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Ligand

Description

1. Ligand: GOL × 7

glycerin

Glycerol

PDB codes: 1lot(B), 2v52(B), 4b1w(B), 6nas(A), 6nbe(A).

2. Ligand: 211 × 2

trolamine

2,2',2''-Nitrilotriethanol

PDB codes: 2hmp(A),

3. Ligand: EDO × 52

1,2-Ethanediol

PDB codes: 1yxq(A), 2asm(A), 2hmp(A), 4b1v(A), 4h03(B), 4h0t(B), 4h0v(B), 4h0x(B), 4h0y(B), 6gvc(B),

4. Ligand: 9ZK × 4

(4~{r},7~{r},10~{s},13~{s},15~{e},19~{s})-10-(4- Azanylbutyl)-4-(4-Hydroxyphenyl)-7-(1~{h}-Indol-3-
Ylmethyl)-8,13,15,19-Tetramethyl-1-Oxa-5,8,11- Triazacyclononadec-15-Ene-2,6,9,12-Tetrone

PDB codes: 5ooc(A), 5ood(A), 6t23(A), 6t24(A).

5. Ligand: MPD × 4

(4s)-2-Methyl-2,4-Pentanediol

PDB codes: 2a5x(A), 3tu5(A), 5ubo(A).

6. Ligand: KAB × 3

Kabiramide c

PDB codes: 1qz5(A), 2q36(A), 4k41(A).

7. Ligand: RLZ × 3

~{N}-[4-[(4~{r},7~{r},10~{s},13~{s},15~{e},19~{s})-4- (4-Hydroxyphenyl)-7-(1~{h}-Indol-3-Ylmethyl)-
8,13,15, 19-Tetramethyl-2,6,9,12-Tetrakis(oxidanylidene)-1-Oxa- 5,8,11-Triazacyclononadec-15-En-
10-Yl]butyl]-~{N}'-[5- Methoxy-2-[(~{Z})-(3,4,5-Trimethoxyphenyl) diazenyl]phenyl]butanediamide

PDB codes: 7ahn(C), 7ahq(A).

8. Ligand: TRP-EEP-ALA-DTH-CYS-HYP-ALA × 3

EEP=(2s,4r)-2-Amino-4,5-Dihydroxy-4-Methylpentanoic acid, DTH=D-Threonine, HYP=4-Hydroxyproline.

PDB codes: 6t1y(A), 6t20(A), 6t25(A).

9. Ligand: CV9 × 2

(2~{r},3~{r},5~{s},6~{e},8~{e},10~{z},12~{s},13~{r}, 16~{z},18~{e},20~{z},22~{e},24~{r},25~{s},
26~{e}, 28~{z})-13-[(2~{s},3~{s},5~{s})-3,5-Bis(oxidanyl) hexan-2-Yl]-25-
[(2~{r},3~{r},4~{s},5~{r},6~{r})-3,4- Dimethoxy-6-Methyl-5-Oxidanyl-Oxan-2-Yl]oxy-3-Methoxy-
2,12,22,24-Tetramethyl-5-Oxidanyl-14,32-Dioxa-33- Azabicyclo[28.2.1]tritriaconta-
1(33),6,8,10,16,18,20, 22,26,28,30-Undecaen-15-One

PDB codes: 6qri(B),

10. Ligand: LO3 × 2

(1s,3s,4s,5s,7r,8s,9r,12e,14e,16r,17r,19r)-16-Hydroxy- 9-{(1s,2s,3s)-2-Hydroxy-5-[(2s,4r,6s)-4-
Methoxy-6- Methyltetrahydro-2h-Pyran-2-Yl]-1,3-Dimethylpentyl}-3, 5,7,17-Tetramethoxy-8,14-
Dimethyl-11h-Spiro[10,23- Dioxabicyclo[17.3.1]tricosa-12,14,20-Triene-4,2'- Oxiran]-11-One

PDB codes: 3m6g(A),

11. Ligand: PEG × 2

Di(hydroxyethyl)ether

PDB codes: 4b1y(B),

12. Ligand: PXT × 2

Pectenotoxin-2

PDB codes: 2q0r(A), 2q0u(A).

13. Ligand: RHO × 2

Tetramethylrhodamine-5-Maleimide

PDB codes: 1j6z(A), 1nwk(A).

14. Ligand: SO4 × 2

Sulfate ion

PDB codes: 3cjc(A), 4b1w(B).

_Ca

15. Metal: _CA × 2

PDB codes: 1j6z(A), 1nwk(A).

16. Ligand: 1PE × 1

Pentaethylene glycol

PDB code: 4b1y(B).

17. Ligand: 1PO × 1

N-{(1e,4r,5r,7e,9s,10s,11s)-4,10-Dimethoxy-11-[(2s,4s, 5s)-2-(4-Methoxyphenyl)-5-Methyl-1,3-Dioxan-
4-Yl]-5,9- Dimethyl-6-Oxododeca-1,7-Dien-1-Yl}-N-Methylformamide

PDB code: 4k43(A).

18. Ligand: ACT × 1

Acetate ion

PDB code: 4eah(D).

19. Ligand: AP8 × 1

(8r,9r,10r,11r,14s,18s,20s,24s)-24-{(1r,2s,3r,6r,7r, 8r,9s,10e)-8-(Acetyloxy)-6-[(N,N-
Dimethylalanyl)oxy]- 11-[Formyl(methyl)amino]-2-Hydroxy-1,3,7,9- Tetramethylundec-10-Enyl}-10-
Hydroxy-14,20-Dimethoxy- 9,11,15,18-Tetramethyl-2-Oxooxacyclotetracosa-3,5,15, 21-Tetraen-8-
Yl n,N,O-Trimethylserinate

PDB code: 1wua(A).

20. Ligand: AR6 × 1

[(2r,3s,4r,5r)-5-(6-Aminopurin-9-Yl)-3,4-Dihydroxy- Oxolan-2-Yl]methyl [hydroxy-[[(2r,3s,4r,5s)-
3,4,5- Trihydroxyoxolan-2-Yl]methoxy]phosphoryl] hydrogen phosphate

PDB code: 4h0t(B).

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Cluster 2 contains 10 ligand types

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Ligand

Description

1. Ligand: GOL × 4

glycerin

Glycerol

PDB codes: 4b1z(A), 6nas(A), 6nbe(A).

_Mg

2. Metal: _MG × 1

PDB code: 1yxq(A).

3. Ligand: EDO × 10

1,2-Ethanediol

PDB codes: 2hmp(A), 4h03(B), 4h0t(B), 4h0v(B), 4h0x(B), 4h0y(B), 6w7v(A).

4. Ligand: 9ZK × 4

(4~{r},7~{r},10~{s},13~{s},15~{e},19~{s})-10-(4- Azanylbutyl)-4-(4-Hydroxyphenyl)-7-(1~{h}-Indol-3-
Ylmethyl)-8,13,15,19-Tetramethyl-1-Oxa-5,8,11- Triazacyclononadec-15-Ene-2,6,9,12-Tetrone

PDB codes: 5ooc(A), 5ood(A), 6t23(A), 6t24(A).

5. Ligand: TRP-EEP-ALA-DTH-CYS-HYP-ALA × 3

EEP=(2s,4r)-2-Amino-4,5-Dihydroxy-4-Methylpentanoic acid, DTH=D-Threonine, HYP=4-Hydroxyproline.

PDB codes: 6t1y(A), 6t20(A), 6t25(A).

6. Ligand: RLZ × 2

PDB codes: 7ahn(C), 7ahq(A).

_Ca

7. Metal: _CA × 2

PDB codes: 1j6z(A), 3m6g(A).

8. Ligand: EEP-ALA-ALO-CYS-HYP-ALA-TRP × 1

EEP=(2s,4r)-2-Amino-4,5-Dihydroxy-4-Methylpentanoic acid, ALO=Allo-Threonine, HYP=4-Hydroxyproline.

PDB code: 6u96(A).

9. Ligand: HYP-ALA-TRP-EEP-ALA-DTH-CYS × 1

HYP=4-Hydroxyproline, EEP=(2s,4r)-2-Amino-4,5-Dihydroxy-4-Methylpentanoic acid, DTH=D-Threonine.

PDB code: 7ad9(B).

10. Ligand: HYP-ALA-TRP-G5G-ALA-ALO-CYS × 1

HYP=4-Hydroxyproline, G5G=(2s,4s)-2-Amino-4,5-Dihydroxy-4-Methylpentanoic acid, ALO=Allo-Threonine.

PDB code: 6w17(I).

Cluster 3 contains 10 ligand types

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Ligand

Description

_Mg

1. Metal: _MG × 14

PDB codes: 1ijj(A), 1rfq(A), 2yje(A), 2yjf(A), 3j8a(A), 3jbi(A), 3jbj(A), 3jbk(A), 6bih(C), 6bno(A), 6bnp(A), 6bnq(A).

2. Ligand: GOL × 1

glycerin

Glycerol

PDB code: 1lot(B).

3. Ligand: ATP × 102

Adenosine-5'-Triphosphate

PDB codes: 1eqy(A), 1esv(A), 1h1v(A), 1ijj(A), 1kxp(A), 1lcu(A), 1lot(B), 1ma9(B), 1p8z(A), 1qz5(A), 1qz6(A), 1rdw(X), 1rfq(A), 1rgi(A), 1s22(A), 1t44(A), 1wua(A), 1y64(A), 1yxq(A), 2a3z(A), 2a40(A), 2a41(A), 2a42(A), 2asm(A), 2aso(A), 2asp(A), 2d1k(A), 2ff3(B), 2ff6(A), 2fxu(A), 2gwj(A), 2gwk(A), 2hmp(A), 2pav(A), 2pbd(A), 2q0r(A), 2q0u(A), 2q31(A), 2q36(A), 2q97(A), 2v51(B), 2v52(B), 2vcp(A), 2yje(A), 2yjf(A), 3buz(B), 3cjb(A), 3cjc(A), 3daw(A), 3ffk(B), 3hbt(A), 3m1f(A), 3m3n(A), 3m6g(A), 3mn5(A), 3sjh(A), 3tpq(A), 3tu5(A), 3u8x(A), 3ue5(A), 4b1v(A), 4b1w(B), 4b1x(B), 4b1y(B), 4b1z(A), 4eah(D), 4gy2(B), 4h03(B), 4h0t(B), 4h0v(B), 4h0x(B), 4h0y(B), 4k41(A), 4pkg(A), 4pki(A), 4pl8(A), 4v0u(A), 4wyb(A), 4z94(A), 5ubo(A), 5yee(B), 5ypu(A), 5zza(A), 5zzb(B), 6gvc(B), 6jbk(A), 6jcu(A), 6jh8(A), 6jh9(A), 6nas(A), 6nbe(A), 6qri(B), 6w7v(A), 6yp9(A), 7c2f(A), 7c2g(A), 7c2h(A).

4. Ligand: ADP × 64

Adenosine-5'-Diphosphate

PDB codes: 1j6z(A), 1sqk(A), 2y83(O), 2zwh(A), 3j4k(A), 3j8a(A), 3j8i(D), 3jbi(A), 3jbj(A), 3jbk(A), 3mfp(A), 3u9z(A), 4a7f(A), 4a7h(A), 4a7l(A), 4a7n(A), 4k42(A), 4k43(A), 4pkh(A), 5h53(D), 5jlf(A), 5mva(A), 5mvy(A), 5onv(A), 5ooc(A), 5ood(A), 5oof(A), 6av9(C), 6avb(C), 6bih(C), 6bno(A), 6bnp(A), 6bnq(A), 6c1d(A), 6c1g(A), 6c1h(A), 6fhl(A), 6fm2(A), 6kn7(A), 6kn8(A), 6mgo(A), 6rsw(A), 6t1y(A), 6t20(A), 6t23(A), 6t24(A), 6t25(A), 6u96(A), 6uby(A), 6uc0(A), 6uc4(A), 6vao(D), 6vau(B), 6vec(A), 6w17(I), 6wvt(B), 7ad9(B), 7ahn(C), 7ahq(A), 7ccc(A).

5. Ligand: LAB × 20

Latrunculin b

PDB codes: 2q0u(A), 2v51(B), 2v52(B), 2yje(B), 2yjf(A), 3mn5(A), 4b1v(A), 4b1w(B), 4b1x(B), 4b1y(B), 4v0u(A), 5yee(B), 5zza(A), 5zzb(B), 6gvc(B), 6nas(A), 6nbe(A), 6w7v(A), 7c2f(A).

6. Ligand: LAR × 17

Latrunculin a

PDB codes: 1esv(A), 1ijj(A), 1lcu(A), 1rdw(X), 1rfq(A), 1sqk(A), 2a5x(A), 2q1n(A), 2q31(A), 3buz(B), 3sjh(A), 4gy2(B), 4h03(B), 4h0t(B), 4h0v(B), 4h0x(B), 4h0y(B).

_Ca

7. Metal: _CA × 10