_EC 1.14.99.66 [histone-H3]-N(6),N(6)-dimethyl-L-lysine(4) FAD-dependent demethylase.

134 PDB entries

EC 1.-.-.- Oxidoreductases. [21,435 PDB entries] EC 1.14.-.- Acting on paired donors, with incorporation or reduction of molecu [4,709 PDB entries] EC 1.14.99.- Miscellaneous. [379 PDB entries] EC 1.14.99.66 [histone-H3]-N(6),N(6)-dimethyl-L-lysine(4) FAD-dependent demethylase. [134 PDB entries]

2com

Reaction:		N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)- [histone H3] + 2 formaldehyde + 2 AH2.
		N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 × A + 2 × H2O = L-lysyl(4)- [histone H3] + 2 × formaldehyde + 2 × AH2 Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Other name(s):		lysine-specific histone demethylase 1.
Comments:		The enzyme specifically removes methyl groups from mono- and dimethylated lysine(4) of histone 3. During the reaction the substrate is oxidized by the Fad cofactor of the enzyme to generate the corresponding imine, which is subsequently hydrolyzed in the form of formaldehyde. The enzyme is similar to flavin amine oxidases, and differs from all other known histone lysine demethylases, which are iron(II)- and 2-oxoglutarate-dependent dioxygenases. The physiological electron acceptor is not known with certainty. In vitro the enzyme can use oxygen, which is reduced to hydrogen
Links:		[IntEnz]   [ExPASy]   [KEGG]

There are 134 PDB entries in enzyme class E.C.1.14.99.66

PDB code		Protein
2com		The solution structure of the swirm domain of human lsd1 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lsd1. Other_details: cell-free protein synthesis Chain: A (124 residues) CATH domain: 1.10.10.10
2dw4		Crystal structure of human lsd1 at 2.3 a resolution Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (634 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
2ejr		Lsd1-tranylcypromine complex Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (643 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
2h94		Crystal structure and mechanism of human lysine-specific demethylase-1 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: aof2. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (647 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
2hko		Crystal structure of lsd1 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: aof2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chain: A (647 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
2iw5		Structural basis for corest-dependent demethylation of nucleosomes by the human lsd1 histone demethylase Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
2l3d		The solution structure of the short form swirm domain of lsd1 Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (102 residues) CATH domain: 1.10.10.10
2uxn		Structural basis of histone demethylation by lsd1 revealed by suicide inactivation Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Synthetic: yes. Organism_taxid: 9606 Chain: A (664 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80 Bound ligand:   Het Group ALA is 40.00% similar to enzyme product formaldehyde
2uxx		Human lsd1 histone demethylase-corest in complex with an fad- tranylcypromine adduct Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Chain: A (665 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
2v1d		Structural basis of lsd1-corest selectivity in histone h3 recognition Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606 Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
2x0l		Crystal structure of a neuro-specific splicing variant of human histone lysine demethylase lsd1. Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606 Chain: A (670 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
2xaf		Crystal structure of lsd1-corest in complex with para-bromo-(+)-cis-2- phenylcyclopropyl-1-amine Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562 Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
2xag		Crystal structure of lsd1-corest in complex with para-bromo-(-)-trans- 2-phenylcyclopropyl-1-amine Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562 Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
2xah		Crystal structure of lsd1-corest in complex with (+)-trans-2- phenylcyclopropyl-1-amine Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562 Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
2xaj		Crystal structure of lsd1-corest in complex with (-)-trans-2- phenylcyclopropyl-1-amine Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562 Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
2xaq		Crystal structure of lsd1-corest in complex with a tranylcypromine derivative (mc2584, 13b) Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562 Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
2xas		Crystal structure of lsd1-corest in complex with a tranylcypromine derivative (mc2580, 14e) Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562 Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
2y48		Crystal structure of lsd1-corest in complex with a n-terminal snail peptide Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606 Chain: A (665 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
2z3y		Crystal structure of lysine-specific demethylase1 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kiaa0601, lsd1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Chain: A (643 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
2z5u		Crystal structure of lysine-specific histone demethylase 1 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kiaa0601, lsd1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Chain: A (642 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
3abt		Crystal structure of lsd1 in complex with trans-2- pentafluorophenylcyclopropylamine Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kazusa DNA kiaa 0601. Expressed in: escherichia coli. Expression_system_taxid: 511693. Chain: A (643 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
3abu		Crystal structure of lsd1 in complex with a 2-pcpa derivative, s1201 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kazusa DNA kiaa 0601. Expressed in: escherichia coli. Expression_system_taxid: 511693. Chain: A (644 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
3zms		Lsd1-corest in complex with insm1 peptide Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Chain: A (665 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80 Bound ligand:   Het Group GLY is 50.00% similar to enzyme product formaldehyde
3zmt		Lsd1-corest in complex with prsflv peptide Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Chain: A (665 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
3zmu		Lsd1-corest in complex with pksflv peptide Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Chain: A (665 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
3zmv		Lsd1-corest in complex with plsflv peptide Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Chain: A (665 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
3zmz		Lsd1-corest in complex with prsfav peptide Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80 Bound ligand:   Het Group ALA is 40.00% similar to enzyme product formaldehyde
3zn0		Lsd1-corest in complex with prsfaa peptide Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80 Bound ligand:   Het Group ALA is 40.00% similar to enzyme product formaldehyde
3zn1		Lsd1-corest in complex with prlylv peptide Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
4bay		Phosphomimetic mutant of lsd1-8a splicing variant in complex with corest Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Chain: A (670 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
4czz		Histone demethylase lsd1(kdm1a)-corest3 complex Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
4fwe		Native structure of lsd2 /aof1/kdm1b in spacegroup of c2221 at 2.13a Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lsd2. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (750 residues)
4fwf		Complex structure of lsd2/aof1/kdm1b with h3k4 mimic Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lsd2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: chain e are synthesized from company Chain: A (739 residues)
4fwj		Native structure of lsd2/aof1/kdm1b in spacegroup of i222 at 2.9a Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lsd2. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B (750 residues)
4gu0		Crystal structure of lsd2 with h3 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lsd2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Synthetic: yes. Other_details: h3k4 is mutated to met Chains: A, B, C, D (748 residues)
4gu1		Crystal structure of lsd2 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lsd2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Chains: A, B (746 residues)
4gur		Crystal structure of lsd2-npac with h3 in space group p21 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lsd2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: glyr1. Expressed in: escherichia coli. Chain: A (734 residues)
4gus		Crystal structure of lsd2-npac with h3 in space group p3221 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lsd2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: glyr1. Expressed in: escherichia coli. Chain: A (746 residues)
4gut		Crystal structure of lsd2-npac Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lsd2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: glyr1. Expressed in: escherichia coli. Chain: A (740 residues)
4guu		Crystal structure of lsd2-npac with tranylcypromine Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lsd2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: glyr1. Expressed in: escherichia coli. Chain: A (740 residues)
4hsu		Crystal structure of lsd2-npac with h3(1-26)in space group p21 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lsd2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: glyr1. Expressed in: escherichia coli. Chain: A (737 residues)
4kum		Structure of lsd1-corest-tetrahydrofolate complex Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: aof2, kdm1, kdm1a, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 511693. Gene: rcor1, hcg_24743. Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
4uv8		Lsd1(kdm1a)-corest in complex with 1-benzyl-tranylcypromine Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Expression_system_taxid: 511693 Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
4uv9		Lsd1(kdm1a)-corest in complex with 1-ethyl-tranylcypromine Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
4uva		Lsd1(kdm1a)-corest in complex with 1-methyl-tranylcypromine (1r,2s) Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
4uvb		Lsd1(kdm1a)-corest in complex with 1-methyl-tranylcypromine (1s,2r) Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Expression_system_taxid: 511693 Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
4uvc		Lsd1(kdm1a)-corest in complex with 1-phenyl-tranylcypromine Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Expression_system_taxid: 511693 Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
4uxn		Lsd1(kdm1a)-corest in complex with z-pro derivative of mc2580 Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
4xbf		Structure of lsd1:corest in complex with ssrna Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: rcor1, kiaa0071, rcor. Synthetic: yes. Organism_taxid: 9606 Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
5h6q		Crystal structure of lsd1-corest in complex with peptide 11 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Synthetic: yes. Organism_taxid: 9606 Chain: A (661 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
5h6r		Crystal structure of lsd1-corest in complex with peptide 13 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Synthetic: yes. Organism_taxid: 9606 Chain: A (662 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
5it3		Swirm domain of human lsd1 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333. Chains: A, B (85 residues) CATH domain: 1.10.10.10
5l3b		Human lsd1/corest: lsd1 d556g mutation Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: rp+. Gene: rcor1, kiaa0071, rcor. Expression_system_variant: rosetta Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
5l3c		Human lsd1/corest: lsd1 e379k mutation Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: rcor1, kiaa0071, rcor. Expression_system_variant: rosetta Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
5l3d		Human lsd1/corest: lsd1 y761h mutation Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: rcor1, kiaa0071, rcor. Expression_system_variant: rosetta Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
5l3e		Lsd1-corest1 in complex with quinazoline-derivative reversible inhibitor Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: rp plus. Gene: rcor1, kiaa0071, rcor. Expression_system_variant: rosetta Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
5l3f		Lsd1-corest1 in complex with polymyxin b Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: rp plus. Gene: rcor1, kiaa0071, rcor. Expression_system_variant: rosetta. Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
5l3g		Lsd1-corest1 in complex with polymyxin e (colistin) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: rp plus. Gene: rcor1, kiaa0071, rcor. Expression_system_variant: rosetta. Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
5lbq		Lsd1-corest1 in complex with quinazoline-derivative reversible inhibitor Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Gene: rcor1, kiaa0071, rcor. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
5lgn		Thieno[3,2-b]pyrrole-5-carboxamides as novel reversible inhibitors of histone lysine demethylase kdm1a/lsd1: compound 19 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 511693. Gene: rcor1, kiaa0071, rcor. Chain: A (670 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
5lgt		Thieno[3,2-b]pyrrole-5-carboxamides as novel reversible inhibitors of histone lysine demethylase kdm1a/lsd1: compound 15 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Expression_system_taxid: 562 Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
5lgu		Thieno[3,2-b]pyrrole-5-carboxamides as novel reversible inhibitors of histone lysine demethylase kdm1a/lsd1: compound 34 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Expression_system_taxid: 562 Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
5lhg		Structure of the kdm1a/corest complex with the inhibitor 4-methyl-n- [4-[[4-(1-methylpiperidin-4-yl)oxyphenoxy]methyl]phenyl]thieno[3,2- b]pyrrole-5-carboxamide Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Expression_system_taxid: 562 Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
5lhh		Structure of the kdm1a/corest complex with the inhibitor 4-ethyl-n-[3- (methoxymethyl)-2-[[4-[[(3r)-pyrrolidin-3- yl]methoxy]phenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamide Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Expression_system_taxid: 562 Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
5lhi		Structure of the kdm1a/corest complex with the inhibitor n-[3- (ethoxymethyl)-2-[[4-[[(3r)-pyrrolidin-3- yl]methoxy]phenoxy]methyl]phenyl]-4-methylthieno[3,2-b]pyrrole-5- carboxamide Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Expression_system_taxid: 562 Chain: A (666 residues) CATH domains: 1.10.10.10 Unassigned 1.10.287.80
5x60		Crystal structure of lsd1-corest in complex with peptide 9 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Synthetic: yes. Organism_taxid: 9606 Chain: A (662 residues)
5yjb		Lsd1-corest in complex with 4-[5-(piperidin-4-ylmethoxy)-2-(p-tolyl) pyridin-3-yl]benzonitrile Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Expressed in: escherichia coli krx. Expression_system_taxid: 1452720. Chain: A (661 residues)
6e1f		Crystal structure of the swirm domain of human histone lysine-specific demethylase lsd1 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B, C, D (89 residues)
6k3e		Lsd1/co-rest structure with an inhibitor Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: codon plus. Gene: rcor1, kiaa0071, rcor. Expressed in: escherichia coli. Chain: A (661 residues) Bound ligand:   Het Group ACT is 50.00% similar to enzyme product formaldehyde
6kgk		Lsd1-corest-s2101 five-membered ring adduct model Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Expressed in: escherichia coli krx. Expression_system_taxid: 1452720. Chain: A (661 residues)
6kgl		Lsd1-corest-s2101 n5 adduct model Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Expressed in: escherichia coli krx. Expression_system_taxid: 1452720. Chain: A (661 residues)
6kgm		Lsd1-corest-s2116 five-membered ring adduct model Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Expressed in: escherichia coli krx. Expression_system_taxid: 1452720. Chain: A (661 residues)
6kgn		Lsd1-corest-s2116 n5 adduct model Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Expressed in: escherichia coli krx. Expression_system_taxid: 1452720. Chain: A (661 residues)
6kgo		Lsd1-s2157 five-membered ring adduct model Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (647 residues)
6kgp		Lsd1-s2157 n5 adduct model Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (647 residues)
6kgq		Lsd1-fcpa-mpe five-membered ring adduct model Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (651 residues)
6kgr		Lsd1-fcpa-mpe n5 adduct model Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (651 residues)
6nqm		Crystal structure of human lsd1 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (636 residues)
6nqu		Human lsd1 in complex with gsk2879552 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (636 residues)
6nr5		Human lsd1 in complex with phenelzine sulfate Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (636 residues)
6r1u		Structure of lsd2/npac-linker/nucleosome core particle complex: class 2 Source: Xenopus laevis. African clawed frog. Organism_taxid: 8355. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_variant: plyss. Gene: hist1h2aj, loc494591. Synthetic: yes. Synthetic construct. Chain: K (737 residues)
6r25		Structure of lsd2/npac-linker/nucleosome core particle complex: class 3 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1b, aof1, c6orf193, lsd2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Xenopus laevis. African clawed frog. Chain: K (737 residues)
6s35		Lsd1/corest1 complex with macrocyclic peptide inhibitor Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Synthetic: yes. Synthetic construct. Chain: A (662 residues) Bound ligand:   Het Group ALA is 40.00% similar to enzyme product formaldehyde
6te1		Structure of the kdm1a/corest complex with the inhibitor 2-[3-{4- chloro-3-[(4-chlorophenyl)ethynyl]phenyl}-1-(3-morpholin-4-ylpropyl)- 1,4,6,7-tetrahydro-5h-pyrazolo[4,3-c]pyridin-5-yl]-2-oxoethanol Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Expression_system_taxid: 562 Chain: A (666 residues)
6tuy		Human lsd1/corest bound to the quinazoline inhibitor mc4106 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Gene: rcor1, kiaa0071, rcor. Expression_system_taxid: 511693 Chain: A (667 residues)
6vyp		Crystal structure of the lsd1/corest histone demethylase bound to its nucleosome substrate Source: Xenopus laevis. African clawed frog. Organism_taxid: 8355. Gene: xelaev_18002543mg. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic construct. Organism_taxid: 32630. Homo sapiens. Chains: M, m, K, k (666 residues)
6w4k		Crystal structure of lysine specific demethylase 1 (lsd1) with cc- 90011 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Expression_system_taxid: 562 Chain: A (651 residues)
6wc6		Crystal structure of a truncated lsd1:corest in the presence of an lsd1-nt peptide Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: rcor1, kiaa0071, rcor. Expression_system_taxid: 469008 Chains: A, C (666 residues)
7cdc		Crystal structure of lsd1-corest in complex with prsflvrrp peptide Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Synthetic: yes. Organism_taxid: 9606 Chain: A (661 residues)
7cdd		Crystal structure of lsd1-corest in complex with prsflvrr peptide Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Synthetic: yes. Organism_taxid: 9606 Chain: A (661 residues)
7cde		Crystal structure of lsd1-corest in complex with prsflvrkr peptide Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Synthetic: yes. Organism_taxid: 9606 Chain: A (661 residues)
7cdf		Crystal structure of lsd1-corest in complex with prsflvrrk peptide Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Synthetic: yes. Organism_taxid: 9606 Chain: A (663 residues)
7cdg		Crystal structure of lsd1-corest in complex with prsflvrrr peptide Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Synthetic: yes. Organism_taxid: 9606 Chain: A (661 residues)
7e0g		Crystal structure of lysine specific demethylase 1 (lsd1) with tak- 418, fad-adduct Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (641 residues)
7vqs		Crystal structure of lsd1 in complex with compound 4 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (647 residues)
7vqt		Crystal structure of lsd1 in complex with compound 5 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (647 residues)
7vqu		Crystal structure of lsd1 in complex with compound s1427 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (645 residues)
7w3l		Crystal structure of lsd1 in complex with cis-4-br-2,5-f2-pcpa (s1024) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (647 residues)
7xe1		Crystal structure of lsd2 in complex with cis-4-br-pcpa Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1b, aof1, c6orf193, lsd2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108 Chains: A, B (751 residues)
7xe2		Crystal structure of lsd2 in complex with trans-4-br-pcpa Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1b, aof1, c6orf193, lsd2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108 Chains: A, B (751 residues)
7xe3		Crystal structure of lsd2 in complex with cis-4-br-2,5-f2-pcpa (s1024) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1b, aof1, c6orf193, lsd2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108 Chains: A, B (747 residues) Bound ligand:   Het Group EDO is 50.00% similar to enzyme product formaldehyde
7xw8		Crystal structure of lysine specific demethylase 1 (lsd1) with tak-418 distomer, fad-adduct Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (639 residues)
7zry		Structure of the 2a splicing variant of the full-length human lsd1 bound to corest (delta305) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Gene: rcor1, kiaa0071, rcor. Expression_system_taxid: 511693 Chain: A (665 residues)
8bop		Lsd1-corest in complex with aw4, long soaking Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Expression_system_taxid: 562 Chain: A (666 residues)
8box		Lsd1-corest in complex with aw4 and snag peptide Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Synthetic: yes. Organism_taxid: 9606 Chain: A (666 residues)
8f2z		Lsd1-corest in complex with aw2, short soaking Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Gene: rcor1, kiaa0071, rcor. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (664 residues)
8f30		Lsd1-corest in complex with aw2, long soaking Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Expression_system_taxid: 562 Chain: A (664 residues)
8f59		Lsd1-corest in complex with aw2 and snag peptide Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Synthetic: yes. Organism_taxid: 9606 Chain: A (666 residues)
8f6s		Lsd1-corest in complex with t105 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Expression_system_taxid: 562 Chain: A (665 residues)
8fdv		Lsd1-corest in complex n-formyl fad and snag peptide Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Gene: snai1, snah. Expression_system_taxid: 562 Chain: A (666 residues)
8fj4		Lsd1-corest in complex with t108, short soaking Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Expression_system_taxid: 562 Chain: A (666 residues)
8fj7		Lsd1-corest in complex with t108 and snag peptide Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Synthetic: yes. Organism_taxid: 9606 Chain: A (666 residues)
8fqj		Lsd1-corest in complex with t14, short soaking Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Expression_system_taxid: 562 Chain: A (666 residues)
8fri		Lsd1-corest in complex with aw4, short soaking Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Expression_system_taxid: 562 Chain: A (666 residues)
8frq		Lsd1-corest in complex with t14, long soaking Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Expression_system_taxid: 562 Chain: A (666 residues)
8frv		Lsd1-corest in complex with t17, short soaking Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Expression_system_taxid: 562 Chain: A (666 residues)
8fsk		Lsd1-corest in complex with t18, short soaking Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Expression_system_taxid: 562 Chain: A (666 residues)
8gj6		Lsd1-corest in complex with t16 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Expression_system_taxid: 562 Chain: A (666 residues)
8inl		Lsd1 in complex with s2172 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (648 residues)
8jf5		Crystal structure of lysine specific demethylase 1 (lsd1) with tas1440 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Expression_system_taxid: 562 Chain: A (662 residues)
8q1g		Lsd1-corest bound to acetylated k14 of histone h3 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Gene: rcor1, kiaa0071, rcor. Synthetic: yes. Organism_taxid: 9606 Chain: A (666 residues)
8q1h		Lsd1 y391k-corest bound to histone h3 n-terminal tail Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Gene: rcor1, kiaa0071, rcor. Synthetic: yes. Organism_taxid: 9606 Chain: A (666 residues)
8q1j		Lsd1 y391k-corest bound to acetylated k14 of histone h3 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Gene: rcor1, kiaa0071, rcor. Synthetic: yes. Organism_taxid: 9606 Chain: A (666 residues)
8ul6		Lsd1-corest in complex with t16, long soaking Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Expression_system_taxid: 562 Chain: A (666 residues)
8ul8		Lsd1-corest in complex with t15, short soaking Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Expression_system_taxid: 562 Chain: A (666 residues)
8ulb		Lsd1-corest in complex with t17, long soaking Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Expression_system_taxid: 562 Chain: A (666 residues)
8ulc		Lsd1-corest in complex with t15, long soaking Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Expression_system_taxid: 562 Chain: A (666 residues)
8ulz		Lsd1-corest in complex with t18 and snag peptide Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: snai1, snah. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Gene: rcor1, kiaa0071, rcor. Expression_system_taxid: 562 Chain: A (666 residues)
8umq		Lsd1-corest in complex with t18, long soaking Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: rcor1, kiaa0071, rcor. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expression_system_taxid: 562 Chain: A (666 residues)
8uni		Lsd1-corest with n-formyl-fad in complex with h3k4m histone tail Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Expression_system_taxid: 562 Chain: A (666 residues)
8uom		Lsd1-corest with n-formyl-fad in complex with h3dimek4 histone tail Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Synthetic: yes. Organism_taxid: 9606 Chain: A (666 residues) Bound ligand:   Het Group ALA is 40.00% similar to enzyme product formaldehyde
9dwu		Corest complex bound to u2af2 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293f. Gene: rcor1, kiaa0071, rcor. Gene: u2af2, u2af65. Chain: A (666 residues)
9el8		Lsd1-corest in complex with t105 1s2r enantiomer Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Expression_system_taxid: 562 Chain: A (665 residues)
9ela		Lsd1-corest in complex with t108, long soaking Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Expression_system_taxid: 562 Chain: A (666 residues)