PDBsum entry 7cdd

Oxidoreductase/transcription

PDB id: 7cdd

Contents

Protein chains

661 a.a.

132 a.a.

Ligands

PRO-ARG-SER-PHE-LEU-VAL-ARG-ARG

FAD

GOL ×2

Waters ×87

PDB id:

7cdd

Name:

Oxidoreductase/transcription

Title:

Crystal structure of lsd1-corest in complex with prsflvrr peptide

Structure:

Lysine-specific histone demethylase 1a. Chain: a. Synonym: braf35-hdac complex protein bhc110,flavin-containing amine oxidase domain-containing protein 2. Engineered: yes. Rest corepressor 1. Chain: b. Synonym: protein corest. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Synthetic: yes. Organism_taxid: 9606

Resolution:

2.76Å R-factor: 0.205 R-free: 0.227

Authors:

M.Kikuchi,H.Kitagawa,S.Sato,N.Umezawa,T.Higuchi,T.Umehara

Key ref:

H.Kitagawa et al. Structure-Based identification of potent lsd1 inhibit peptides and temporary cyclization to enhance proteol stability and cell growth inhibitory activity. To be published, . PubMed id: 33754721

Date:

19-Jun-20 Release date: 23-Jun-21

Protein chain

O60341  (KDM1A_HUMAN) -  Lysine-specific histone demethylase 1A from Homo sapiens

Seq: 852 a.a.

Struc: 661 a.a.

Protein chain

Q9UKL0  (RCOR1_HUMAN) -  REST corepressor 1 from Homo sapiens

Seq: 485 a.a.

Struc: 132 a.a.

Enzyme reactions

• Enzyme class: Chain A: E.C.1.14.99.66 - [histone-H3]-N(6),N(6)-dimethyl-L-lysine(4) FAD-dependent demethylase.
• Reaction: N₆,N₆-dimethyl-L-lysyl₄-[histone H3] + 2 A + 2 H2O = L-lysyl₄- [histone H3] + 2 formaldehyde + 2 AH2

Molecule diagrams generated from .mol files obtained from the KEGG ftp site