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PDBsum entry 8box
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protein ligands Protein-protein interface(s) links
Oxidoreductase PDB id
8box

 

 

 

 

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Contents
Protein chains
666 a.a.
133 a.a.
Ligands
PRO-ARG-SER-PHE
SV9
PDB id:
8box
Name: Oxidoreductase
Title: Lsd1-corest in complex with aw4 and snag peptide
Structure: Lysine-specific histone demethylase 1a. Chain: a. Synonym: braf35-hdac complex protein bhc110,flavin-containing amine oxidase domain-containing protein 2,[histone h3]-dimethyl-l-lysine(4) fad-dependent demethylase 1a. Engineered: yes. Rest corepressor 1. Chain: b. Synonym: protein corest.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rcor1, kiaa0071, rcor. Synthetic: yes. Organism_taxid: 9606
Resolution:
2.82Å     R-factor:   0.220     R-free:   0.229
Authors: J.Caroli,A.Mattevi
Key ref: J.Caroli and a.mattevi Distal drug resistance mutations promote covalent inhibitor-Adduct grob fragmentation in lsd1. To be published, . PubMed id: 40175327
Date:
15-Nov-22     Release date:   05-Jun-24    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
O60341  (KDM1A_HUMAN) -  Lysine-specific histone demethylase 1A from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		852 a.a.
666 a.a.
Protein chain
Q9UKL0  (RCOR1_HUMAN) -  REST corepressor 1 from Homo sapiens
Seq:
Struc: 		485 a.a.
133 a.a.
Key:    Secondary structure

 Enzyme reactions 
   Enzyme class: Chain A: E.C.1.14.99.66  - [histone-H3]-N(6),N(6)-dimethyl-L-lysine(4) FAD-dependent demethylase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: N6,N6-dimethyl-L-lysyl4-[histone H3] + 2 A + 2 H2O = L-lysyl4- [histone H3] + 2 formaldehyde + 2 AH2
N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3]
 + 2 × A
 + 2 × H2O
 = L-lysyl(4)- [histone H3]
 + 2 × formaldehyde
 + 2 × AH2
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 

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