Edit

Goldman Group

Evolutionary tools for genomic analysis

Evolution is the historical cause of the diversity of all life. The group’s research focuses on the development of data analysis methods for the study of molecular sequence evolution and for the exploitation of evolutionary information to draw powerful and robust inferences about phylogenetic history and genomic function. The evolutionary relationships between all organisms require that we analyse molecular sequences with consideration of the underlying structure relating those sequences.

Edit

Evolution is the historical cause of the diversity of all life. The group’s research focuses on the development of data analysis methods for the study of molecular sequence evolution and for the exploitation of evolutionary information to draw powerful and robust inferences about phylogenetic history and genomic function. The evolutionary relationships between all organisms require that we analyse molecular sequences with consideration of the underlying structure relating those sequences.

Edit

Evolutionary tools for genomic analysis

We develop mathematical, statistical and computational techniques to reveal information present in genome data, to draw inferences about the processes that gave rise to that data and to make predictions about the biology of the systems whose components are encoded in those genomes.

Our three main research activities are: developing new evolutionary models and methods; providing these methods to other scientists via stand-alone software and web services; and applying such techniques to tackle biological questions of interest. We participate in comparative genomic studies, both independently and in collaboration with others, including the analysis of next-generation sequencing (NGS) data. This vast source of new data promises great gains in understanding genomes and brings with it many new challenges.

For a brief multi-lingual look at what we do, click here.

DNA-storage

We were one of the teams that created the modern field of “DNA-storage”, the use of DNA to archive digital information. Click here to find out more about our work on this topic.

Evolutionary trees embedded in low-dimensional space. Credit: Kevin Gori
This is a TreeCloud — like a word cloud, with font size indicating importance/relevance, but additionally with a tree-like structure indicating which terms tend to be used in close proximity with others.  The data in this example comes from the 4-yearly report on the research activity of the Goldman group (2009-13).
 [created with TreeCloud, from Philippe Gambette]

Edit