PDBsum entry 5byt

Transferase/transferase inhibitor

PDB id: 5byt

Contents

Protein chains

343 a.a.

Ligands

PRP ×2

Metals

_MG ×2

Waters ×347

PDB id:

5byt

Name:

Transferase/transferase inhibitor

Title:

Prpp complexed with a single mg in the active site of mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)

Structure:

Anthranilate phosphoribosyltransferase. Chain: a, b. Engineered: yes

Source:

Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: atcc 25618 / h37rv. Gene: trpd, rv2192c, mtcy190.03c. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

2.00Å R-factor: 0.225 R-free: 0.271

Authors:

G.L.Evans,E.N.Baker,J.S.Lott,Tb Structural Genomics Consortium (Tbsgc)

Key ref:

G.L.Evans et al. Binding and mimicking of the phosphate-Rich substrate. To be published, .

Date:

11-Jun-15 Release date: 20-Jul-16

Protein chains

P9WFX5  (TRPD_MYCTU) -  Anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Seq: 370 a.a.

Struc: 343 a.a.

Enzyme reactions

• Enzyme class: E.C.2.4.2.18 - anthranilate phosphoribosyltransferase.
• Pathway: Tryptophan Biosynthesis
• Reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha- D-ribose 1-diphosphate + anthranilate

N-(5-phospho-beta-D-ribosyl)anthranilate (Bound ligand (Het Group name = PRP) matches with 40.91% similarity) + diphosphate = 5-phospho-alpha- D-ribose 1-diphosphate + anthranilate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site