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UniProt functional annotation for P9WFX5 | ||
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| UniProt code: P9WFX5. |
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| Organism: | |
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). |
| Taxonomy: | |
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. |
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| Function: | |
Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). |
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| Catalytic activity: | |
Reaction=diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5- phospho-alpha-D-ribose 1-diphosphate + anthranilate; Xref=Rhea:RHEA:11768, ChEBI:CHEBI:16567, ChEBI:CHEBI:18277, ChEBI:CHEBI:33019, ChEBI:CHEBI:58017; EC=2.4.2.18; Evidence={ECO:0000255|HAMAP-Rule:MF_00211}; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|HAMAP-Rule:MF_00211, ECO:0000269|PubMed:16337227, ECO:0000269|PubMed:23363292, ECO:0000269|Ref.4, ECO:0000269|Ref.5}; Note=Binds 2 magnesium ions per monomer. {ECO:0000255|HAMAP- Rule:MF_00211, ECO:0000269|PubMed:16337227, ECO:0000269|PubMed:23363292, ECO:0000269|Ref.4, ECO:0000269|Ref.5}; |
| Pathway: | |
Amino-acid biosynthesis; L-tryptophan biosynthesis; L- tryptophan from chorismate: step 2/5. {ECO:0000255|HAMAP- Rule:MF_00211}. |
| Subunit: | |
Homodimer. {ECO:0000255|HAMAP-Rule:MF_00211, ECO:0000269|PubMed:16337227, ECO:0000269|PubMed:23363292, ECO:0000269|Ref.4, ECO:0000269|Ref.5}. |
| Similarity: | |
Belongs to the anthranilate phosphoribosyltransferase family. {ECO:0000255|HAMAP-Rule:MF_00211}. |
Annotations taken from UniProtKB at the EBI.