EC 2.4.2.18 - Anthranilate phosphoribosyltransferase

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IntEnz Enzyme Nomenclature
EC 2.4.2.18

Names

Accepted name:
anthranilate phosphoribosyltransferase
Other names:
PRT
anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase
anthranilate phosphoribosylpyrophosphate phosphoribosyltransferase
anthranilate-PP-ribose-P phosphoribosyltransferase
phosphoribosyl-anthranilate pyrophosphorylase
phosphoribosylanthranilate pyrophosphorylase
phosphoribosylanthranilate transferase
Systematic name:
N-(5-phospho-D-ribosyl)-anthranilate:diphosphate phospho-α-D-ribosyltransferase

Reaction

Comments:

In some organisms, this enzyme is part of a multifunctional protein together with one or more other components of the system for biosynthesis of tryptophan [EC 4.1.1.48 (indole-3-glycerol-phosphate synthase), EC 4.1.3.27 (anthranilate synthase), EC 4.2.1.20 (tryptophan synthase) and EC 5.3.1.24 (phosphoribosylanthranilate isomerase)].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004048
CAS Registry Number: 9059-35-2
UniProtKB/Swiss-Prot: (573) [show] [UniProt]

References

  1. Creighton, T.E. and Yanofsky, C.
    Chorismate to tryptophan (Escherichia coli) — Anthranilate synthetase, PR transferase, PRA isomerase, InGP synthetase, tryptophan synthetase.
    Methods Enzymol. 17A: 365-380 (1970).
  2. Hütter, R., Niederberger, P. and DeMoss, J.A.
    Tryptophan biosynthetic genes in eukaryotic microorganisms.
    Annu. Rev. Microbiol. 40: 55-77 (1986). [PMID: 3535653]
  3. Ito, J. and Yanofsky, C.
    Anthranilate synthetase, an enzyme specified by the tryptophan operon of Escherichia coli: Comparative studies on the complex and the subunits.
    J. Bacteriol. 97: 734-742 (1969). [PMID: 4886290]
  4. Wegman, J. and DeMoss, J.A.
    The enzymatic conversion of anthranilate to indolylglycerol phosphate in Neurospora crassa.
    J. Biol. Chem. 240: 3781-3788 (1965). [PMID: 5842052]

[EC 2.4.2.18 created 1972]