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The Crystal Structures of a Swine SLA-2*HB01 Molecules Complexed with a CTL epitope from Asia1 serotype of Foot-and-mouth disease virus

Source organisms:
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 3.6.1.15: Nucleoside-triphosphate phosphatase

Reaction catalysed:
NTP + H(2)O = NDP + phosphate
Systematic name:
Unspecific diphosphate phosphohydrolase
Alternative Name(s):
  • NTPase
  • Nucleoside 5-triphosphatase
  • Nucleoside triphosphate hydrolase
  • Nucleoside triphosphate phosphohydrolase
  • Nucleoside-5-triphosphate phosphohydrolase
  • Nucleoside-triphosphatase

EC 3.4.22.46: L-peptidase

Reaction catalysed:
Autocatalytically cleaves itself from the polyprotein of the foot-and-mouth disease virus by hydrolysis of a Lys-|-Gly bond, but then cleaves host cell initiation factor eIF-4G at bonds -Gly-|-Arg- and -Lys-|-Arg-.
Systematic name:
-

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF07654
Domain description: Immunoglobulin C1-set domain
Occurring in:
  1. Ig-like domain-containing protein
  2. Beta-2-microglobulin
The deposited structure of PDB entry 8gqv contains 2 copies of Pfam domain PF07654 (Immunoglobulin C1-set domain) in Ig-like domain-containing protein. Showing 1 copy in chain A.
The deposited structure of PDB entry 8gqv contains 2 copies of Pfam domain PF07654 (Immunoglobulin C1-set domain) in Beta-2-microglobulin. Showing 1 copy in chain B.

PF00129
Domain description: Class I Histocompatibility antigen, domains alpha 1 and 2
Occurring in:
  1. Ig-like domain-containing protein
The deposited structure of PDB entry 8gqv contains 2 copies of Pfam domain PF00129 (Class I Histocompatibility antigen, domains alpha 1 and 2) in Ig-like domain-containing protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. Ig-like domain-containing protein
  2. Beta-2-microglobulin
IPR001039
Domain description: MHC class I alpha chain, alpha1 alpha2 domains
Occurring in:
  1. Ig-like domain-containing protein
IPR015707
Domain description: Beta-2-Microglobulin
Occurring in:
  1. Beta-2-microglobulin
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. Ig-like domain-containing protein
  2. Beta-2-microglobulin
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. Ig-like domain-containing protein
  2. Beta-2-microglobulin
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. Ig-like domain-containing protein
  2. Beta-2-microglobulin
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Ig-like domain-containing protein
  2. Beta-2-microglobulin
IPR011162
Domain description: MHC classes I/II-like antigen recognition protein
Occurring in:
  1. Ig-like domain-containing protein
IPR011161
Domain description: MHC class I-like antigen recognition-like
Occurring in:
  1. Ig-like domain-containing protein
IPR037055
Domain description: MHC class I-like antigen recognition-like superfamily
Occurring in:
  1. Ig-like domain-containing protein

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