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Human histidine decarboxylase mutant Y334F reacted with histidine

X-ray diffraction
2.1Å resolution
PDB entry 7eiw coloured by chain, front view.
PDB entry 7eiw coloured by chain, side view.
PDB entry 7eiw coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Histidine decarboxylase
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Multimeric state: homo dimer
Accessible surface area: 31100.81 Å2
Buried surface area: 13174.79 Å2
Dissociation area: 6,124.88 Å2
Dissociation energy (ΔGdiss): 106.3 kcal/mol
Dissociation entropy (TΔSdiss): 15.95 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-148502

Macromolecules

Histidine decarboxylase
Chains: A, B
Length: 481 amino acids
Theoretical weight: 54.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19113 (Residues: 2-477; Coverage: 72%)
Gene name: HDC
Pfam: Pyridoxal-dependent decarboxylase conserved domain
InterPro:
Histidine decarboxylase in PDB entry 7eiw, assembly 1, front view.
Histidine decarboxylase in PDB entry 7eiw, assembly 1, side view.
Histidine decarboxylase in PDB entry 7eiw, assembly 1, top view.
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