Aromatic-L-amino-acid decarboxylase (IPR010977)

Short name: Aromatic_deC

Overlapping homologous superfamilies

Family relationships


A number of pyridoxal-dependent decarboxylases share regions of sequence similarity, particularly in the vicinity of a conserved lysine residue, which provides the attachment site for the pyridoxal-phosphate (PLP) group [PMID: 8181483, PMID: 2124279]. Among these enzymes are aromatic-L-amino-acid decarboxylase (L-dopa decarboxylase or tryptophan decarboxylase), which catalyses the decarboxylation of tryptophan to tryptamine [PMID: 8889823]; tyrosine decarboxylase, which converts tyrosine into tyramine; and histidine decarboxylase, which catalyses the decarboxylation of histidine to histamine [PMID: 2300558]. These enzymes belong to the group II decarboxylases [PMID: 8181483, PMID: 8889823].

GO terms

Biological Process

GO:0006520 cellular amino acid metabolic process

Molecular Function

GO:0016831 carboxy-lyase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.