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Structure of a MAPK pathway complex

Electron Microscopy
5.7Å resolution
PDB entry 6q0t coloured by chain, front view.
PDB entry 6q0t coloured by chain, side view.
PDB entry 6q0t coloured by chain, top view.
Source organisms:
Assembly composition:
hetero pentamer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
PDBe Complex ID: PDB-CPX-147201

Macromolecules

Serine/threonine-protein kinase B-raf
Chains: A, B
Length: 805 amino acids
Theoretical weight: 89.31 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P15056 (Residues: 1-766; Coverage: 100%)
Gene names: BRAF, BRAF1, RAFB1
Pfam:
InterPro:
Serine/threonine-protein kinase B-raf in PDB entry 6q0t, assembly 1, front view.
Serine/threonine-protein kinase B-raf in PDB entry 6q0t, assembly 1, side view.
Serine/threonine-protein kinase B-raf in PDB entry 6q0t, assembly 1, top view.
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Dual specificity mitogen-activated protein kinase kinase 1
Chain: C
Length: 414 amino acids
Theoretical weight: 45.84 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q02750 (Residues: 1-392; Coverage: 100%)
Gene names: MAP2K1, MEK1, PRKMK1
Pfam: Protein kinase domain
InterPro:
Dual specificity mitogen-activated protein kinase kinase 1 in PDB entry 6q0t, assembly 1, front view.
Dual specificity mitogen-activated protein kinase kinase 1 in PDB entry 6q0t, assembly 1, side view.
Dual specificity mitogen-activated protein kinase kinase 1 in PDB entry 6q0t, assembly 1, top view.
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14-3-3 domain-containing protein
Chains: X, Y
Length: 247 amino acids
Theoretical weight: 28.11 KDa
Source organism: Spodoptera exigua
UniProt:
  • Canonical: V9P4T4 (Residues: 1-247; Coverage: 100%)
Pfam: 14-3-3 protein
InterPro:
14-3-3 domain-containing protein in PDB entry 6q0t, assembly 1, front view.
14-3-3 domain-containing protein in PDB entry 6q0t, assembly 1, side view.
14-3-3 domain-containing protein in PDB entry 6q0t, assembly 1, top view.
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