Diacylglycerol/phorbol-ester binding (IPR020454)

Short name: DAG/PE-bd

Domain relationships



Diacylglycerol (DAG) is an important second messenger. Phorbol esters (PE) are analogues of DAG and potent tumour promoters that cause a variety of physiological changes when administered to both cells and tissues. DAG activates a family of serine/threonine protein kinases, collectively known as protein kinase C (PKC) [PMID: 1396661]. Phorbol esters can directly stimulate PKC. The N-terminal region of PKC, known as C1, has been shown [PMID: 2500657] to bind PE and DAG in a phospholipid and zinc-dependent fashion. The C1 region contains one or two copies (depending on the isozyme of PKC) of a cysteine-rich domain, which is about 50 amino-acid residues long, and which is essential for DAG/PE-binding. The DAG/PE-binding domain binds two zinc ions; the ligands of these metal ions are probably the six cysteines and two histidines that are conserved in this domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.