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17beta-hydroxysteroid dehydrogenase type 14 mutant K158A in complex with Nicotinamide Adenine Dinucleotide

X-ray diffraction
1.25Å resolution
PDB entry 6h0m coloured by chain, front view.
PDB entry 6h0m coloured by chain, side view.
PDB entry 6h0m coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: 17-beta-hydroxysteroid dehydrogenase 14
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Multimeric state: homo tetramer
Accessible surface area: 32059.65 Å2
Buried surface area: 24119.11 Å2
Dissociation area: 5,963.94 Å2
Dissociation energy (ΔGdiss): 91.77 kcal/mol
Dissociation entropy (TΔSdiss): 15.6 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-189654

Macromolecules

17-beta-hydroxysteroid dehydrogenase 14
Chain: A
Length: 270 amino acids
Theoretical weight: 28.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: Q9BPX1 (Residues: 1-270; Coverage: 100%)
Gene names: DHRS10, HSD17B14, SDR3, SDR47C1, UNQ502/PRO474
Pfam: Enoyl-(Acyl carrier protein) reductase
InterPro:
17-beta-hydroxysteroid dehydrogenase 14 in PDB entry 6h0m, assembly 1, front view.
17-beta-hydroxysteroid dehydrogenase 14 in PDB entry 6h0m, assembly 1, side view.
17-beta-hydroxysteroid dehydrogenase 14 in PDB entry 6h0m, assembly 1, top view.
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