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17beta-hydroxysteroid dehydrogenase type 14 mutant K158A in complex with Nicotinamide Adenine Dinucleotide

Source organism: Homo sapiens
Biochemical function: testosterone 17-beta-dehydrogenase (NADP+) activity
Biological process: steroid metabolic process
Cellular component: cytosol

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EC 1.1.1.62: 17-beta-estradiol 17-dehydrogenase

Reaction catalysed:
17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H
Systematic name:
17-beta-estradiol:NAD(P)(+) 17-oxidoreductase
Alternative Name(s):
  • 17-beta,20-alpha-hydroxysteroid dehydrogenase
  • 17-beta-HSD
  • 17-beta-estradiol dehydrogenase
  • 17-beta-hydroxysteroid dehydrogenase
  • 20-alpha-hydroxysteroid dehydrogenase
  • Estradiol dehydrogenase
  • Estrogen 17-oxidoreductase
  • HSD17B7

GO terms

Sequence family

Pfam Protein family (Pfam)
PF13561
Domain description: Enoyl-(Acyl carrier protein) reductase
Occurring in:
  1. 17-beta-hydroxysteroid dehydrogenase 14
The deposited structure of PDB entry 6h0m contains 1 copy of Pfam domain PF13561 (Enoyl-(Acyl carrier protein) reductase) in 17-beta-hydroxysteroid dehydrogenase 14. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002347
Domain description: Short-chain dehydrogenase/reductase SDR
Occurring in:
  1. 17-beta-hydroxysteroid dehydrogenase 14
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. 17-beta-hydroxysteroid dehydrogenase 14

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