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The human methylenetetrahydrofolate dehydrogenase/cyclohydrolase (FolD) complexed with NADP and inhibitor LY345899

X-ray diffraction
2.7Å resolution
PDB entry 6ecq coloured by chain, front view.
PDB entry 6ecq coloured by chain, side view.
PDB entry 6ecq coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed
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Multimeric state: homo dimer
Accessible surface area: 24235.61 Å2
Buried surface area: 4926.58 Å2
Dissociation area: 1,385.35 Å2
Dissociation energy (ΔGdiss): 8.17 kcal/mol
Dissociation entropy (TΔSdiss): 13.59 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-145878

Macromolecules

C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed
Chains: A, B
Length: 296 amino acids
Theoretical weight: 32.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P11586 (Residues: 1-296; Coverage: 32%)
Gene names: MTHFC, MTHFD, MTHFD1
Pfam:
InterPro:
C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed in PDB entry 6ecq, assembly 1, front view.
C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed in PDB entry 6ecq, assembly 1, side view.
C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed in PDB entry 6ecq, assembly 1, top view.
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