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Crystal structure of HIV-1 Protease NL4-3 I84V Mutant in complex with UMass6

X-ray diffraction
1.978Å resolution
PDB entry 6dh2 coloured by chain, front view.
PDB entry 6dh2 coloured by chain, side view.
PDB entry 6dh2 coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Peptidase A2 domain-containing protein
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Multimeric state: homo dimer
Accessible surface area: 9214.53 Å2
Buried surface area: 4105.31 Å2
Dissociation area: 1,994.62 Å2
Dissociation energy (ΔGdiss): 23.34 kcal/mol
Dissociation entropy (TΔSdiss): 11.52 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-182323

Macromolecules

Peptidase A2 domain-containing protein
Chains: A, B
Length: 99 amino acids
Theoretical weight: 10.82 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7ZCI0 (Residues: 1-99; Coverage: 100%)
Gene name: pol
Pfam: Retroviral aspartyl protease
InterPro:
CATH: Acid Proteases
Peptidase A2 domain-containing protein in PDB entry 6dh2, assembly 1, front view.
Peptidase A2 domain-containing protein in PDB entry 6dh2, assembly 1, side view.
Peptidase A2 domain-containing protein in PDB entry 6dh2, assembly 1, top view.
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