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Crystal structure of the primed SNARE-Complexin-Synaptotagmin-1 C2AB complex

Source organism: Rattus norvegicus
Biochemical function: syntaxin binding
Biological process: vesicle-mediated transport
Cellular component: membrane

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF00168
Domain description: C2 domain
Occurring in:
  1. Synaptotagmin-1
The deposited structure of PDB entry 5w5c contains 2 copies of Pfam domain PF00168 (C2 domain) in Synaptotagmin-1. Showing 2 copies in chain F.

PF05835
Domain description: Synaphin protein
Occurring in:
  1. Complexin-1
The deposited structure of PDB entry 5w5c contains 1 copy of Pfam domain PF05835 (Synaphin protein) in Complexin-1. Showing 1 copy in chain E.

PF05739
Domain description: SNARE domain
Occurring in:
  1. Syntaxin-1A
The deposited structure of PDB entry 5w5c contains 1 copy of Pfam domain PF05739 (SNARE domain) in Syntaxin-1A. Showing 1 copy in chain B.

PF00957
Domain description: Synaptobrevin
Occurring in:
  1. Vesicle-associated membrane protein 2
The deposited structure of PDB entry 5w5c contains 1 copy of Pfam domain PF00957 (Synaptobrevin) in Vesicle-associated membrane protein 2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000008
Domain description: C2 domain
Occurring in:
  1. Synaptotagmin-1
IPR000727
Domain description: Target SNARE coiled-coil homology domain
Occurring in:
  1. Syntaxin-1A
  2. Synaptosomal-associated protein 25
  3. Synaptosomal-associated protein 25
IPR001565
Domain description: Synaptotagmin
Occurring in:
  1. Synaptotagmin-1
IPR035892
Domain description: C2 domain superfamily
Occurring in:
  1. Synaptotagmin-1
IPR001388
Domain description: Synaptobrevin-like
Occurring in:
  1. Vesicle-associated membrane protein 2
IPR042855
Domain description: v-SNARE, coiled-coil homology domain
Occurring in:
  1. Vesicle-associated membrane protein 2
IPR008849
Domain description: Synaphin
Occurring in:
  1. Complexin-1
IPR039077
Domain description: SNAP25, N-terminal SNARE motif, chordates
Occurring in:
  1. Synaptosomal-associated protein 25
IPR006012
Domain description: Syntaxin/epimorphin, conserved site
Occurring in:
  1. Syntaxin-1A
IPR045242
Domain description: Syntaxin
Occurring in:
  1. Syntaxin-1A
IPR010989
Domain description: SNARE
Occurring in:
  1. Syntaxin-1A
IPR006011
Domain description: Syntaxin, N-terminal domain
Occurring in:
  1. Syntaxin-1A
IPR016444
Domain description: Synaptobrevin/Vesicle-associated membrane protein
Occurring in:
  1. Vesicle-associated membrane protein 2

Structure domains

CATH CATH domains
2.60.40.150
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: C2 domain
Occurring in:
  1. Synaptotagmin-1
The deposited structure of PDB entry 5w5c contains 2 copies of CATH domain 2.60.40.150 (Immunoglobulin-like) in Synaptotagmin-1. Showing 2 copies in chain F.
1.20.5.110
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Occurring in:
  1. Synaptosomal-associated protein 25
The deposited structure of PDB entry 5w5c contains 1 copy of CATH domain 1.20.5.110 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in Synaptosomal-associated protein 25. Showing 1 copy in chain D.

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