Family

Synaptobrevin/Vesicle-associated membrane protein (IPR016444)

Short name: Synaptobrevin/VAMP_met/fun

Family relationships

None.

Description

This entry includes vesicle-associated membrane proteins (VAMPs) and Synaptobrevins.

Synaptobrevin is an intrinsic membrane protein of small synaptic vesicles [PMID: 2560644], specialised secretory organelles of neurons that actively accumulate neurotransmitters and participate in their calcium-dependent release by exocytosis. Vesicle function is mediated by proteins in their membranes, although the precise nature of the protein-protein interactions underlying this are still uncertain [PMID: 1976629]. Synaptobrevin may play a role in the molecular events underlying neurotransmitter release and vesicle recycling and may be involved in the regulation of membrane flow in the nerve terminal, a process mediated by interaction with low molecular weight GTP-binding proteins [PMID: 8406010]. Synaptic vesicle-associated membrane proteins (VAMPs) from Torpedo californica (Pacific electric ray) and SNC1 from yeast are related to synaptobrevin.

VAMP family is a group of small, integral membrane proteins of synaptic vesicles that is mostly involved in vesicle fusion. Neurotransmitter release involves the assembly of a heterotrimeric SNARE complex composed of SNAP25, VAMP2 and syntaxin 1 [PMID: 12145198]. VAMP2 plays a specific role in the insulin-dependent recruitment of GLUT4 from its intracellular storage compartment to the cell surface [PMID: 9430681].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF