Synaptobrevin/Vesicle-associated membrane protein (IPR016444)

Short name: Synaptobrevin/VAMP

Overlapping homologous superfamilies


Family relationships


This entry includes vesicle-associated membrane proteins VAMP1/synaptobrevin-1, VAMP2/synaptobrevin-2, VAMP3/synaptobrevin-3 and VAMP8/endobrevin.

VAMPs are a group of small, integral membrane proteins of synaptic vesicles that is mostly involved in vesicle fusion. The heterotrimeric SNARE complex is formed by syntaxin 1, synaptosomal-associated protein 25 kDa (SNAP25), and vesicle-associated membrane protein (VAMP)/synaptobrevin [PMID: 8221884]. VAMP1 plays an essential, non-redundant role in Ca2+-triggered vesicle exocytosis at the mouse neuromuscular junction [PMID: 21282288]. VAMP2 is extensively expressed in the central nervous system [PMID: 12145198]. Neurotransmitter release involves the assembly of a heterotrimeric SNARE complex composed of SNAP25, VAMP2 and syntaxin 1 [PMID: 12145198]. VAMP8 may be involved in regulated exocytosis of the exocrine system [PMID: 15363411, PMID: 17215514].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.