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Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 2-(pyridin-4-yl)thiazolidine-4-carboxylic acid

X-ray diffraction
2.03Å resolution
PDB entry 5cew coloured by chain, front view.
PDB entry 5cew coloured by chain, side view.
PDB entry 5cew coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Malate synthase G
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Multimeric state: monomeric
Accessible surface area: 27040.37 Å2
Buried surface area: 97.94 Å2
Dissociation area: 48.97 Å2
Dissociation energy (ΔGdiss): 11.24 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-161718

Macromolecules

Malate synthase G
Chain: A
Length: 741 amino acids
Theoretical weight: 80.46 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P9WK17 (Residues: 1-741; Coverage: 100%)
Gene names: MTCY1A11.06, Rv1837c, glcB
Pfam:
InterPro:
CATH:
Malate synthase G in PDB entry 5cew, assembly 1, front view.
Malate synthase G in PDB entry 5cew, assembly 1, side view.
Malate synthase G in PDB entry 5cew, assembly 1, top view.
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