Malate synthase G (IPR006253)

Short name: Malate_synthG

Overlapping homologous superfamilies

Family relationships


Malate synthase G (MSG, 723 residues) is an enzyme of the glyoxylate pathway, that catalyzes the Claisen condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA [PMID: 12930982], this biochemical bypass is used by microorganisms (bacteria, yeast, and fungi) for biosynthesis under anaerobic conditions [PMID: 13430766]. Enzymes of the glyoxylate bypass have been implicated as virulence factors in several pathogens, including Mycobacterium tuberculosis [PMID: 10963578, PMID: 10963599, PMID: 11452311].

The X-ray structure of the ternary abortive complex of MSG with pyruvate (glyoxylate mimic) and acetyl-CoA has been determined [PMID: 12930982] and shown to have the same structure as in the complex with glyoxylate [PMID: 10715138].

GO terms

Biological Process

GO:0006097 glyoxylate cycle

Molecular Function

GO:0004474 malate synthase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.