› › Function and Biology

Crystal structure of TrmD, a M1G37 tRNA Methyltransferase with SAM-competitive compounds

Source organism: Haemophilus influenzae Rd KW20
Biochemical function: tRNA (guanine(37)-N1)-methyltransferase activity
Biological process: methylation
Cellular component: cytosol

Quick links

EC 2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase

Reaction catalysed:
S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA
Systematic name:
S-adenosyl-L-methionine:tRNA (guanine(37)-N(1))-methyltransferase
Alternative Name(s):
  • MJ0883 (gene name)
  • TRMT5
  • Transfer RNA (m(1)G(37)) methyltransferase
  • Trm5p
  • TrmD
  • tRNA (m(1)G(37)) methyltransferase
  • tRNA-(N(1)G37) methyltransferase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01746
Domain description: tRNA (Guanine-1)-methyltransferase
Occurring in:
  1. tRNA (guanine-N(1)-)-methyltransferase
The deposited structure of PDB entry 4yq9 contains 1 copy of Pfam domain PF01746 (tRNA (Guanine-1)-methyltransferase) in tRNA (guanine-N(1)-)-methyltransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002649
Domain description: tRNA (guanine-N1-)-methyltransferase TrmD
Occurring in:
  1. tRNA (guanine-N(1)-)-methyltransferase
IPR023148
Domain description: tRNA (guanine-N(1)-)-methyltransferase, C-terminal domain superfamily
Occurring in:
  1. tRNA (guanine-N(1)-)-methyltransferase
IPR016009
Domain description: tRNA methyltransferase TRMD/TRM10-type domain
Occurring in:
  1. tRNA (guanine-N(1)-)-methyltransferase
IPR029028
Domain description: Alpha/beta knot methyltransferases
Occurring in:
  1. tRNA (guanine-N(1)-)-methyltransferase
IPR029026
Domain description: tRNA (guanine-N1-)-methyltransferase, N-terminal
Occurring in:
  1. tRNA (guanine-N(1)-)-methyltransferase

Structure domains

CATH CATH domains
1.10.1270.20
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Trp Operon Repressor; Chain A
Homology: tRNA(m1g37)methyltransferase, domain 2
Occurring in:
  1. tRNA (guanine-N(1)-)-methyltransferase
The deposited structure of PDB entry 4yq9 contains 1 copy of CATH domain 1.10.1270.20 (Trp Operon Repressor; Chain A) in tRNA (guanine-N(1)-)-methyltransferase. Showing 1 copy in chain A.
3.40.1280.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Alpha/beta knot
Homology: Alpha/beta knot
Occurring in:
  1. tRNA (guanine-N(1)-)-methyltransferase
The deposited structure of PDB entry 4yq9 contains 1 copy of CATH domain 3.40.1280.10 (Alpha/beta knot) in tRNA (guanine-N(1)-)-methyltransferase. Showing 1 copy in chain A.

Quick links