Homologous Superfamily

tRNA (guanine-N1-)-methyltransferase, C-terminal (IPR023148)

Short name: tRNA_m1G_MeTrfase_C

Overlapping entries


In transfer RNA many different modified nucleosides are found, especially in the anticodon region. tRNA (guanine (N1))-methyltransferase EC: is one of several nucleases operating together with the tRNA-modifying enzymes before the formation of the mature tRNA. It catalyses the reaction: S-adenosyl-L-methionine + guanine37 in tRNA -> S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine

It methylates guanosine(G) to N1-methylguanine (1-methylguanosine (m1G)) at position 37 of tRNAs that read CUN (leucine), CCN(proline), and CGG (arginine) codons. The presence of m1G improves the cellular growth rate and the polypeptide steptime and also prevents the tRNA from shifting the reading frame [PMID: 2207153].

This entry represents the C-terminal structural domain.

GO terms

Biological Process

GO:0008033 tRNA processing

Molecular Function

GO:0052906 tRNA (guanine(37)-N(1))-methyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.