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Crystal structure of HIV-1 broadly neutralizing antibody PGT151

X-ray diffraction
1.862Å resolution
PDB entry 4nug coloured by chain, front view.
PDB entry 4nug coloured by chain, side view.
PDB entry 4nug coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: IG-heavy chain and IG-light lambda chain
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Multimeric state: hetero dimer
Accessible surface area: 21354.42 Å2
Buried surface area: 4552.92 Å2
Dissociation area: 1,960.02 Å2
Dissociation energy (ΔGdiss): 17.03 kcal/mol
Dissociation entropy (TΔSdiss): 13.32 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-186187

Macromolecules

Ig-like domain-containing protein
Chain: L
Length: 219 amino acids
Theoretical weight: 24.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8TCD0 (Residues: 21-239; Coverage: 100%)
Pfam:
InterPro:
CATH: Immunoglobulins
Ig-like domain-containing protein in PDB entry 4nug, assembly 1, front view.
Ig-like domain-containing protein in PDB entry 4nug, assembly 1, side view.
Ig-like domain-containing protein in PDB entry 4nug, assembly 1, top view.
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Ig-like domain-containing protein
Chain: H
Length: 240 amino acids
Theoretical weight: 26.09 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: S6BAM6 (Residues: 20-124, 125-129, 130-249; Coverage: 76%)
Pfam:
InterPro:
CATH: Immunoglobulins
Ig-like domain-containing protein in PDB entry 4nug, assembly 1, front view.
Ig-like domain-containing protein in PDB entry 4nug, assembly 1, side view.
Ig-like domain-containing protein in PDB entry 4nug, assembly 1, top view.
Molecule details ›

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