› 4nug

X-ray diffraction
1.86Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186187 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ig-like domain-containing protein Chain: L
Molecule details ›
Chain: L
Length: 219 amino acids
Theoretical weight: 24.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8TCD0 (Residues: 21-239; Coverage: 100%)
Sequence domains:
Structure domains: Immunoglobulins
Ig-like domain-containing protein Chain: H
Molecule details ›
Chain: H
Length: 240 amino acids
Theoretical weight: 26.09 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: S6BAM6 (Residues: 20-124, 125-129, 130-249; Coverage: 76%)
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand P6G 2 x P6G
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: C2
Unit cell:
a: 118.645Å b: 66.977Å c: 84.552Å
α: 90° β: 133.91° γ: 90°
R-values:
R R work R free
0.161 0.159 0.207
Expression system: Homo sapiens

Quick links

Citations

55 review citations

Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design.
Burton et al. (2016)
54 more

5 mentions without citation

Antiviral Therapy by HIV-1 Broadly Neutralizing and Inhibitory Antibodies.
Zhang et al. (2016)
4 more