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Human ecto-5'-nucleotidase (CD73): crystal form I (open) in complex with adenosine

X-ray diffraction
1.85Å resolution
PDB entry 4h2f coloured by chain, front view.
PDB entry 4h2f coloured by chain, side view.
PDB entry 4h2f coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: 5'-nucleotidase
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Multimeric state: homo dimer
Accessible surface area: 37730.25 Å2
Buried surface area: 4955.77 Å2
Dissociation area: 1,657.86 Å2
Dissociation energy (ΔGdiss): 6.22 kcal/mol
Dissociation entropy (TΔSdiss): 14.9 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-149316

Macromolecules

5'-nucleotidase
Chain: A
Length: 546 amino acids
Theoretical weight: 60.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P21589 (Residues: 27-549; Coverage: 95%)
Gene names: NT5, NT5E, NTE
Pfam:
InterPro:
CATH:
5'-nucleotidase in PDB entry 4h2f, assembly 1, front view.
5'-nucleotidase in PDB entry 4h2f, assembly 1, side view.
5'-nucleotidase in PDB entry 4h2f, assembly 1, top view.
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