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Crystal structure of the intracellular domain of human APP (T668E mutant) in complex with Fe65-PTB2

X-ray diffraction
2.2Å resolution
PDB entry 3dxd coloured by chain, front view.
PDB entry 3dxd coloured by chain, side view.
PDB entry 3dxd coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Amyloid-beta protein 40/42 complex and Amyloid beta precursor protein binding family B member 1
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Multimeric state: hetero dimer
Accessible surface area: 8261.17 Å2
Buried surface area: 2122.2 Å2
Dissociation area: 1,061.1 Å2
Dissociation energy (ΔGdiss): 10.76 kcal/mol
Dissociation entropy (TΔSdiss): 9.73 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126156
Assembly 2
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Assembly Name: Amyloid-beta protein 40/42 complex and Amyloid beta precursor protein binding family B member 1
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Multimeric state: hetero dimer
Accessible surface area: 7752.33 Å2
Buried surface area: 2072.81 Å2
Dissociation area: 1,036.41 Å2
Dissociation energy (ΔGdiss): 10.19 kcal/mol
Dissociation entropy (TΔSdiss): 9.61 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126156

Macromolecules

Amyloid beta precursor protein binding family B member 1
Chains: A, C
Length: 140 amino acids
Theoretical weight: 15.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00213 (Residues: 534-667; Coverage: 19%)
Gene names: APBB1, FE65, RIR
Pfam: Phosphotyrosine interaction domain (PTB/PID)
InterPro:
CATH: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Amyloid beta precursor protein binding family B member 1 in PDB entry 3dxd, assembly 1, front view.
Amyloid beta precursor protein binding family B member 1 in PDB entry 3dxd, assembly 1, side view.
Amyloid beta precursor protein binding family B member 1 in PDB entry 3dxd, assembly 1, top view.
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C31
Chains: B, D
Length: 35 amino acids
Theoretical weight: 4.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05067 (Residues: 739-770; Coverage: 4%)
Gene names: A4, AD1, APP
Pfam: Beta-amyloid precursor protein C-terminus
InterPro:
C31 in PDB entry 3dxd, assembly 1, front view.
C31 in PDB entry 3dxd, assembly 1, side view.
C31 in PDB entry 3dxd, assembly 1, top view.
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