Domain

Beta-amyloid precursor protein C-terminal (IPR019543)

Short name: APP_amyloid_C

Domain relationships

None.

Description

This is the amyloid, C-terminal, protein of the beta-Amyloid precursor protein (APP) which is a conserved and ubiquitous transmembrane glycoprotein strongly implicated in the pathogenesis of Alzheimer's disease but whose normal biological function is unknown. The C-terminal 100 residues are released and aggregate into amyloid deposits which are strongly implicated in the pathology of Alzheimer's disease plaque-formation. The domain is associated with IPR008154, further towards the N terminus.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam