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Crystal structure of Mycobacterium tuberculosis RNase PH, the Mycobacterium tuberculosis Structural Genomics Consortium target Rv1340

Source organism: Mycobacterium tuberculosis H37Rv
Biochemical function: nucleotidyltransferase activity
Biological process: rRNA catabolic process
Cellular component: plasma membrane

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EC 2.7.7.56: tRNA nucleotidyltransferase

Reaction catalysed:
tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate
Systematic name:
tRNA:phosphate nucleotidyltransferase
Alternative Name(s):
  • Phosphate-dependent exonuclease
  • RNase PH
  • Ribonuclease PH

GO terms

Sequence families

Pfam Protein families (Pfam)
PF03725
Domain description: 3' exoribonuclease family, domain 2
Occurring in:
  1. Ribonuclease PH
The deposited structure of PDB entry 3b4t contains 6 copies of Pfam domain PF03725 (3' exoribonuclease family, domain 2) in Ribonuclease PH. Showing 1 copy in chain A.

PF01138
Domain description: 3' exoribonuclease family, domain 1
Occurring in:
  1. Ribonuclease PH
The deposited structure of PDB entry 3b4t contains 6 copies of Pfam domain PF01138 (3' exoribonuclease family, domain 1) in Ribonuclease PH. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002381
Domain description: Ribonuclease PH, bacterial-type
Occurring in:
  1. Ribonuclease PH
IPR015847
Domain description: Exoribonuclease, phosphorolytic domain 2
Occurring in:
  1. Ribonuclease PH
IPR036345
Domain description: Exoribonuclease, PH domain 2 superfamily
Occurring in:
  1. Ribonuclease PH
IPR018336
Domain description: Ribonuclease PH, conserved site
Occurring in:
  1. Ribonuclease PH
IPR001247
Domain description: Exoribonuclease, phosphorolytic domain 1
Occurring in:
  1. Ribonuclease PH
IPR027408
Domain description: PNPase/RNase PH domain superfamily
Occurring in:
  1. Ribonuclease PH
IPR020568
Domain description: Ribosomal protein uS5 domain 2-type superfamily
Occurring in:
  1. Ribonuclease PH

Structure domain

CATH CATH domain
3.30.230.70
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Ribosomal Protein S5; domain 2
Homology: GHMP Kinase, N-terminal domain
Occurring in:
  1. Ribonuclease PH
The deposited structure of PDB entry 3b4t contains 6 copies of CATH domain 3.30.230.70 (Ribosomal Protein S5; domain 2) in Ribonuclease PH. Showing 1 copy in chain A.

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