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Structure of adenylate kinase 1 in complex with P1,P4-di(adenosine) tetraphosphate

X-ray diffraction
1.71Å resolution
PDB entry 2c95 coloured by chain, front view.
PDB entry 2c95 coloured by chain, side view.
PDB entry 2c95 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Adenylate kinase isoenzyme 1
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Multimeric state: monomeric
Accessible surface area: 9188.26 Å2
Buried surface area: 1646.24 Å2
Dissociation area: 143.29 Å2
Dissociation energy (ΔGdiss): -3.09 kcal/mol
Dissociation entropy (TΔSdiss): 1.21 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132721
Assembly 2
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Assembly Name: Adenylate kinase isoenzyme 1
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Multimeric state: monomeric
Accessible surface area: 9235.17 Å2
Buried surface area: 1634.53 Å2
Dissociation area: 134.25 Å2
Dissociation energy (ΔGdiss): -3.07 kcal/mol
Dissociation entropy (TΔSdiss): 1.2 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132721

Macromolecules

Adenylate kinase isoenzyme 1
Chains: A, B
Length: 196 amino acids
Theoretical weight: 21.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00568 (Residues: 1-193; Coverage: 100%)
Gene name: AK1
Pfam: Adenylate kinase
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
Adenylate kinase isoenzyme 1 in PDB entry 2c95, assembly 1, front view.
Adenylate kinase isoenzyme 1 in PDB entry 2c95, assembly 1, side view.
Adenylate kinase isoenzyme 1 in PDB entry 2c95, assembly 1, top view.
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