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Structure of adenylate kinase 1 in complex with P1,P4-di(adenosine) tetraphosphate

Source organism: Homo sapiens
Biochemical function: nucleoside triphosphate adenylate kinase activity
Biological process: nucleoside monophosphate phosphorylation
Cellular component: extracellular exosome

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EC 2.7.4.6: Nucleoside-diphosphate kinase

Reaction catalysed:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
Systematic name:
ATP:nucleoside-diphosphate phosphotransferase
Alternative Name(s):
  • NDK
  • Nucleoside 5'-diphosphate kinase
  • Nucleoside 5'-diphosphate phosphotransferase
  • Nucleoside diphosphate (UDP) kinase
  • Nucleoside diphosphokinase
  • Nucleotide phosphate kinase
  • UDP kinase
  • Uridine diphosphate kinase

EC 2.7.4.3: Adenylate kinase

Reaction catalysed:
ATP + AMP = 2 ADP
Systematic name:
ATP:AMP phosphotransferase
Alternative Name(s):
  • 5'-AMP-kinase
  • Adenylic kinase
  • Adenylokinase
  • Myokinase

EC 2.7.4.10: Nucleoside-triphosphate--adenylate kinase

Reaction catalysed:
NTP + AMP = NDP + ADP
Systematic name:
Nucleoside-triphosphate:AMP phosphotransferase
Alternative Name(s):
  • GTP:AMP phosphotransferase
  • Guanosine triphosphate--adenylate kinase
  • Isozyme 3 of adenylate kinase
  • Nucleoside triphosphate--adenosine monophosphate transphosphorylase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00406
Domain description: Adenylate kinase
Occurring in:
  1. Adenylate kinase isoenzyme 1
The deposited structure of PDB entry 2c95 contains 2 copies of Pfam domain PF00406 (Adenylate kinase) in Adenylate kinase isoenzyme 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000850
Domain description: Adenylate kinase/UMP-CMP kinase
Occurring in:
  1. Adenylate kinase isoenzyme 1
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Adenylate kinase isoenzyme 1
IPR033690
Domain description: Adenylate kinase, conserved site
Occurring in:
  1. Adenylate kinase isoenzyme 1
IPR006267
Domain description: Adenylate kinase, isozyme 1/5
Occurring in:
  1. Adenylate kinase isoenzyme 1
IPR028582
Domain description: Adenylate kinase isoenzyme 1
Occurring in:
  1. Adenylate kinase isoenzyme 1

Structure domain

CATH CATH domain
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Adenylate kinase isoenzyme 1
The deposited structure of PDB entry 2c95 contains 2 copies of CATH domain 3.40.50.300 (Rossmann fold) in Adenylate kinase isoenzyme 1. Showing 1 copy in chain A.

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