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Parainfluenza Virus 5 (SV5) Hemagglutinin-Neuraminidase (HN) with ligand DANA (soaked with DANA, pH8.0)

X-ray diffraction
2.7Å resolution
PDB entry 1z4w coloured by chain, front view.
PDB entry 1z4w coloured by chain, side view.
PDB entry 1z4w coloured by chain, top view.
Source organism: Mammalian orthorubulavirus 5
Assemblies composition:
homo tetramer
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Hemagglutinin-neuraminidase
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Multimeric state: homo tetramer
Accessible surface area: 58549.43 Å2
Buried surface area: 16679.6 Å2
Dissociation area: 855.56 Å2
Dissociation energy (ΔGdiss): -7.5 kcal/mol
Dissociation entropy (TΔSdiss): 15.24 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-138213
Assembly 2 (preferred)
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Assembly Name: Hemagglutinin-neuraminidase
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Multimeric state: homo dimer
Accessible surface area: 30104.29 Å2
Buried surface area: 7493.9 Å2
Dissociation area: 1,839.96 Å2
Dissociation energy (ΔGdiss): 21.8 kcal/mol
Dissociation entropy (TΔSdiss): 14.45 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-138212

Macromolecules

Hemagglutinin-neuraminidase
Chain: A
Length: 532 amino acids
Theoretical weight: 58.51 KDa
Source organism: Mammalian orthorubulavirus 5
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P04850 (Residues: 37-565; Coverage: 94%)
Gene name: HN
Pfam: Haemagglutinin-neuraminidase
InterPro:
CATH: Neuraminidase
Hemagglutinin-neuraminidase in PDB entry 1z4w, assembly 2, front view.
Hemagglutinin-neuraminidase in PDB entry 1z4w, assembly 2, side view.
Hemagglutinin-neuraminidase in PDB entry 1z4w, assembly 2, top view.
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