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Crystal Structure of Plasmodium falciparum Purine Nucleoside Phosphorylase in complex with ImmH and Sulfate

X-ray diffraction
2.2Å resolution
PDB entry 1nw4 coloured by chain, front view.
PDB entry 1nw4 coloured by chain, side view.
PDB entry 1nw4 coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Assemblies composition:
homo hexamer
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Purine nucleoside phosphorylase
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Multimeric state: homo hexamer
Accessible surface area: 45437.41 Å2
Buried surface area: 32701.62 Å2
Dissociation area: 8,082.08 Å2
Dissociation energy (ΔGdiss): 28.7 kcal/mol
Dissociation entropy (TΔSdiss): 30.37 kcal/mol
Symmetry number: 6
PDBe Complex ID: PDB-CPX-184666
Assembly 2
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Assembly Name: Purine nucleoside phosphorylase
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Multimeric state: homo dimer
Accessible surface area: 19935.51 Å2
Buried surface area: 5864.2 Å2
Dissociation area: 1,342.22 Å2
Dissociation energy (ΔGdiss): 16.44 kcal/mol
Dissociation entropy (TΔSdiss): 13.09 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-184665
Assembly 3
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Assembly Name: Purine nucleoside phosphorylase
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Multimeric state: homo dimer
Accessible surface area: 19878.45 Å2
Buried surface area: 6639.7 Å2
Dissociation area: 1,338.52 Å2
Dissociation energy (ΔGdiss): 15.54 kcal/mol
Dissociation entropy (TΔSdiss): 13.1 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-184665
Assembly 4
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Assembly Name: Purine nucleoside phosphorylase
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Multimeric state: homo dimer
Accessible surface area: 19972.48 Å2
Buried surface area: 5848.69 Å2
Dissociation area: 1,339.1 Å2
Dissociation energy (ΔGdiss): 15.33 kcal/mol
Dissociation entropy (TΔSdiss): 13.09 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-184665
Assembly 5
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Assembly Name: Purine nucleoside phosphorylase
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Multimeric state: homo dimer
Accessible surface area: 18152.77 Å2
Buried surface area: 8015.46 Å2
Dissociation area: 2,369.43 Å2
Dissociation energy (ΔGdiss): 4.92 kcal/mol
Dissociation entropy (TΔSdiss): 13.39 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-184665
Assembly 6 (preferred)
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Assembly Name: Purine nucleoside phosphorylase
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Multimeric state: homo dimer
Accessible surface area: 18415.69 Å2
Buried surface area: 7011.73 Å2
Dissociation area: 2,281 Å2
Dissociation energy (ΔGdiss): 4.99 kcal/mol
Dissociation entropy (TΔSdiss): 13.36 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-184665
Assembly 7
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Assembly Name: Purine nucleoside phosphorylase
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Multimeric state: homo dimer
Accessible surface area: 18173.98 Å2
Buried surface area: 8369.39 Å2
Dissociation area: 2,500.12 Å2
Dissociation energy (ΔGdiss): -1.53 kcal/mol
Dissociation entropy (TΔSdiss): 13.43 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-184665

Macromolecules

Purine nucleoside phosphorylase
Chains: A, B, C, D, E, F
Length: 276 amino acids
Theoretical weight: 30.5 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8I3X4 (Residues: 2-245; Coverage: 100%)
Gene names: PF3D7_0513300, PNP
Pfam: Phosphorylase superfamily
InterPro:
CATH: Nucleoside phosphorylase domain
SCOP: Purine and uridine phosphorylases
Purine nucleoside phosphorylase in PDB entry 1nw4, assembly 6, front view.
Purine nucleoside phosphorylase in PDB entry 1nw4, assembly 6, side view.
Purine nucleoside phosphorylase in PDB entry 1nw4, assembly 6, top view.
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