Domain

Nucleoside phosphorylase domain (IPR000845)

Short name: Nucleoside_phosphorylase_d

Domain relationships

None.

Description

Phosphorylases with this domain include:

  • Purine nucleoside phosphorylase (EC:2.4.2.1) (PNP) from most bacteria (gene deoD), which catalyses the cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules [PMID: 8534998].
  • Uridine phosphorylase (EC:2.4.2.3) (UdRPase) from bacteria (gene udp) and mammals, which catalyses the cleavage of uridine into uracil and ribose-1-phosphate, the products of the reaction are used either as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis [PMID: 7744869].
  • 5'-methylthioadenosine phosphorylase (EC:2.4.2.28) (MTA phosphorylase) from Sulfolobus solfataricus [PMID: 7929153].
  • Purine nucleoside phosphorylase (EC:2.4.2.1) (PNP) from mammals as well as from some bacteria (gene deoD). This enzyme catalyzes the cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules [PMID: 2104852].
  • 5'-methylthioadenosine phosphorylase (EC:2.4.2.28) (MTA phosphorylase) from eukaryotes [PMID: 8687427].

GO terms

Biological Process

GO:0009116 nucleoside metabolic process

Molecular Function

GO:0003824 catalytic activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam