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Atomic structure of the actin:DNASE I complex

Source organisms:
Biochemical function: protein binding
Biological process: regulation of neutrophil mediated cytotoxicity
Cellular component: zymogen granule

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EC 3.1.21.1: Deoxyribonuclease I

Reaction catalysed:
Endonucleolytic cleavage to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end-products
Alternative Name(s):
  • Alkaline DNase
  • Alkaline deoxyribonuclease
  • DNA depolymerase
  • DNA endonuclease
  • DNA nuclease
  • DNAase
  • DNase
  • DNase I
  • Deoxyribonuclease (pancreatic)
  • Deoxyribonuclease A
  • Deoxyribonucleic phosphatase
  • Dornava
  • Dornavac
  • Endodeoxyribonuclease I
  • Escherichia coli endonuclease I
  • Pancreatic DNase
  • Pancreatic deoxyribonuclease
  • Pancreatic dornase
  • Thymonuclease
  • Thymonuclease, dornase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF03372
Domain description: Endonuclease/Exonuclease/phosphatase family
Occurring in:
  1. Deoxyribonuclease-1
The deposited structure of PDB entry 1atn contains 1 copy of Pfam domain PF03372 (Endonuclease/Exonuclease/phosphatase family) in Deoxyribonuclease-1. Showing 1 copy in chain B [auth D].

PF00022
Domain description: Actin
Occurring in:
  1. Actin, alpha skeletal muscle
The deposited structure of PDB entry 1atn contains 1 copy of Pfam domain PF00022 (Actin) in Actin, alpha skeletal muscle. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR016202
Domain description: Deoxyribonuclease I
Occurring in:
  1. Deoxyribonuclease-1
IPR004000
Domain description: Actin family
Occurring in:
  1. Actin, alpha skeletal muscle
IPR036691
Domain description: Endonuclease/exonuclease/phosphatase superfamily
Occurring in:
  1. Deoxyribonuclease-1
IPR004001
Domain description: Actin, conserved site
Occurring in:
  1. Actin, alpha skeletal muscle
IPR043129
Domain description: ATPase, nucleotide binding domain
Occurring in:
  1. Actin, alpha skeletal muscle
IPR033125
Domain description: Deoxyribonuclease I, conservied site
Occurring in:
  1. Deoxyribonuclease-1
IPR018057
Domain description: Deoxyribonuclease I, active site
Occurring in:
  1. Deoxyribonuclease-1
IPR005135
Domain description: Endonuclease/exonuclease/phosphatase
Occurring in:
  1. Deoxyribonuclease-1
IPR020902
Domain description: Actin/actin-like conserved site
Occurring in:
  1. Actin, alpha skeletal muscle

Structure domains

CATH CATH domains
3.30.420.40
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Nucleotidyltransferase; domain 5
Homology: Nucleotidyltransferase; domain 5
Occurring in:
  1. Actin, alpha skeletal muscle
The deposited structure of PDB entry 1atn contains 2 copies of CATH domain 3.30.420.40 (Nucleotidyltransferase; domain 5) in Actin, alpha skeletal muscle. Showing 2 copies in chain A.
3.60.10.10
Class: Alpha Beta
Architecture: 4-Layer Sandwich
Topology: Deoxyribonuclease I; Chain A
Homology: Endonuclease/exonuclease/phosphatase
Occurring in:
  1. Deoxyribonuclease-1
The deposited structure of PDB entry 1atn contains 1 copy of CATH domain 3.60.10.10 (Deoxyribonuclease I; Chain A) in Deoxyribonuclease-1. Showing 1 copy in chain B [auth D].
3.90.640.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Actin; Chain A, domain 4
Homology: Actin; Chain A, domain 4
Occurring in:
  1. Actin, alpha skeletal muscle
The deposited structure of PDB entry 1atn contains 1 copy of CATH domain 3.90.640.10 (Actin; Chain A, domain 4) in Actin, alpha skeletal muscle. Showing 1 copy in chain A.
2.30.36.70
Class: Mainly Beta
Architecture: Roll
Topology: Actin; Chain A, domain 2
Homology: Actin; Chain A, domain 2
Occurring in:
  1. Actin, alpha skeletal muscle
The deposited structure of PDB entry 1atn contains 1 copy of CATH domain 2.30.36.70 (Actin; Chain A, domain 2) in Actin, alpha skeletal muscle. Showing 1 copy in chain A.
SCOP SCOP annotations
53068
Class: Alpha and beta proteins (a/b)
Fold: Ribonuclease H-like motif
Superfamily: Actin-like ATPase domain
Occurring in:
  1. Actin, alpha skeletal muscle
The deposited structure of PDB entry 1atn contains 2 copies of SCOP domain 53068 (Actin/HSP70) in Actin, alpha skeletal muscle. Showing 2 copies in chain A.
56220
Class: Alpha and beta proteins (a+b)
Fold: DNase I-like
Superfamily: DNase I-like
Occurring in:
  1. Deoxyribonuclease-1
The deposited structure of PDB entry 1atn contains 1 copy of SCOP domain 56220 (DNase I-like) in Deoxyribonuclease-1. Showing 1 copy in chain B [auth D].

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