Homologous Superfamily

Endonuclease/exonuclease/phosphatase superfamily (IPR036691)

Short name: Endo/exonu/phosph_ase_sf

Overlapping entries

Description

This domain superfamily is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling [PMID: 10838565]. This domain is found in many proteins including AP endonuclease proteins (DNA-(apurinic or apyrimidinic site) lyase EC:4.2.99.18), deoxyribonuclease-1 (DNase I; EC:3.1.21.1), synaptojanin an inositol-1,4,5-trisphosphate phosphatase (EC:3.1.3.56) and sphingomyelinase (EC:3.1.4.12).

The DNase I domain structure contains a beta-sandwich fold and a duplication of the alpha+beta motif.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SUPERFAMILY
GENE3D