Homologous Superfamily

Endonuclease/exonuclease/phosphatase superfamily (IPR036691)

Short name: Endo/exonu/phosph_ase_sf

Overlapping entries


This domain superfamily is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling [PMID: 10838565]. This domain is found in many proteins including AP endonuclease proteins (DNA-(apurinic or apyrimidinic site) lyase EC:, deoxyribonuclease-1 (DNase I; EC:, synaptojanin an inositol-1,4,5-trisphosphate phosphatase (EC: and sphingomyelinase (EC:

The DNase I domain structure contains a beta-sandwich fold and a duplication of the alpha+beta motif.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.