Family I68
Summary for family I68
| Name | Inhibitor family I68 (tick CPI family) |
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| Family type peptidase | I68.001 - tick carboxypeptidase inhibitor (Rhipicephalus bursa) (Rhipicephalus bursa), MEROPS Accession MER0046750 (inhibitor unit: 23-97) |
| Content of family | Inhibitor family I68 contains a carboxypeptidase inhibitor. |
| History |
Identifier created: MEROPS 7.0 (4 April 2005)
The carboxypeptidase inhibitor from the tick Rhipicephalus bursa was discovered by Arolas et al. (2005). |
| Peptidases inhibited | Recombinant tick carboxypeptidase inhibitor (TCI) inhibited several carboxypeptidases of subfamily ##M14A##. These included carboxypeptidase U (M14.009), inhibition of which has been suggested to enhance endogenous fibrinolysis. |
| Mechanism of inhibition | TCI is a double-headed inhibitor, with the C-terminal residue occupying the active site of the peptidase similar to the mechanisms of potato carboxypeptidase inhibitor (I37.001) and leech carboxypeptidase inhibitor (I46.001), and the N-terminus interacting with an exosite (Arolas et al., 2005). |
| Molecular structure | The tertiary structure has been determined and shows a fold similar to that of beta-defensin (Arolas et al., 2005). The inhibitor is synthesised as a precursor of 97 amino acid residues with a 22-residue signal peptide and a 75-residue mature protein. The mature protein contains 12 cysteine residues, and is heavily disulfide-bonded. The sequence of the N-terminal region has some similarity to those of potato carboxypeptidase inhibitor and leech carboxypeptidase inhibitor. |
| Clan | JK |
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Distribution of family
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Bacteria |
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Archaea |
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Protozoa |
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Fungi |
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Plants |
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Animals |
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Viruses |
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| Inhibitors and Homologues |
MEROPS ID |
Structure |
| tick carboxypeptidase inhibitor (Rhipicephalus bursa) | I68.001 | Yes |
| tick carboxypeptidase inhibitor (Haemaphysalis longicornis) | I68.002 | - |
| Family I68 unassigned peptidases | unassigned | - |
