Family I42
Summary for family I42
| Name | Inhibitor family I42 (chagasin family) |
|---|
| Family type peptidase | I42.001 - chagasin (Leishmania major), MEROPS Accession MER0018490 (inhibitor unit: 1-117) |
| Content of family | Inhibitor family I42 contains inhibitors of cysteine endopeptidases. |
| History |
Identifier created: MEROPS 6.1 (10 January 2003)
Chagasin was discovered as a protein from Trypanosoma cruzi (the causative agent of Chagas" heart disease) that inhibits cysteine peptidases of family C1 by Monteiro et al., 2001. |
| Peptidases inhibited | Several recombinant chagasins inhibited protozoan and mammalian family C1 cysteine peptidases, but not caspase-3 (C14.003), the serine peptidases trypsin (S01.151) and thrombin (S01.217), or the aspartic peptidase pepsin A (A01.001) (Sanderson et al., 2003). |
| Mechanism of inhibition | Inhibition is reversible and tight-binding (Monteiro et al., 2001). |
| Molecular structure | The tertiary structure of chagasin from Trypanosoma cruzi has been determined showing a single domain consisting of eight beta strands arranged in two beta-sheets, similar to the immunoglobulin fold (Figueiredo da silva et al., 2006). |
| Clan | JL |
