Linking to MEROPS
We encourage other webmasters to make links to MEROPS. However, please note that MEROPS is a framed Web site, so links will work well only if they are constructed in the right way. They need to take advantage of a CGI program on the MEROPS Web site as described below.
Adding a page to your Favorites (Microsoft Internet Explorer) or Bookmarks (Netscape) is easy. Each page in the Database contains a JavaScript function to help you do this. Just click the link "Add this page to your Favorites" at the bottom of the page, and follow the prompts.
If you want to construct links to MEROPS from your own Web site, you will need to know that the format of every link should be like:
http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=VAR1;action=VAR2
The values of VAR1 and VAR2 are the things that you will need to specify in order to retrieve exactly the right page. First decide whether you want to link to MEROPS at the level of a peptidase or inhibitor, a family, a clan, or one of the general pages (such as an index). Select the value for VAR1 from the table below, and then (optionally) select one of the available values for VAR2. (The value of VAR1 is the more important because there are built-in defaults for VAR2 that will often be acceptable.) All the possible (i.e. valid) values are shown in Table 1 below. Some of the values are written with capital letters for clarity, but in fact the values are not case-sensitive.
When working at the peptidase/inhibitor level, please note that there are special kinds of PepCards that contain peptidase that have not yet been assigned to specific identifiers, or peptidase homologues that are known not to be catalytically active. These are stored in files with names that end in "UPW" or "UNW" respectively for a family that has not been divided into subfamilies. Thus, the members of family M1 that have not been assigned to identifiers can be found under M01.UPW, and those that are known not to be peptidases under M01.UNW. For a family that has been divided into subfamilies, there will be files for each subfamily with endings like "UPA", "UNA", "UPB" and UNB", and so on. All inhibitor homologues that have not been assigned to specific codes are stored in files ending in "UNW", "UNA", etc. according to whether the family has been divided into subfamilies.
Table 1
| VAR1 (the 'id' value) | VAR2 (the 'action' value) | Result (page returned) |
|---|---|---|
| Peptidase/Inhibitor level | ||
| VAR1 is the standard MEROPS identifier for the peptidase or inhibitor. Examples: C14.003, A9G.018, LI91-002, S08.UPA Optionally, a point in an identifier can be replaced with "p", so that C14p003 is also valid. |
Summary or default | Summary for the peptidase/inhibitor |
| Sequences | Sequences for the peptidase/inhibitor | |
| Distribution | Distribution of the peptidase/inhibitor | |
| Structure | Structure of the peptidase/inhibitor | |
| Substrates | Some substrates of the peptidase | |
| Literature | Literature for the peptidase/inhibitor | |
| HsESTal | Alignment of the human ESTs | |
| HsESTdt | Data for the human ESTs | |
| MmESTal | Alignment of the mouse ESTs | |
| MmESTdt | Data for the mouse ESTs | |
| Family level | ||
| VAR1 is the standard MEROPS identifier for the family of peptidases or inhibitors. Examples: A1, I25 |
Summary or default | Summary for the family |
| Alignment | Sequence alignment for the family | |
| Tree | Tree for the family | |
| Genomes | Occurrence of the family in whole genomes | |
| Structure | 2D structure diagrams | |
| Literature | Literature for the family | |
| Hsseq | Human sequences in the family | |
| Mmseq | Mouse sequences in the family | |
| Animals | Animal species from which the family is known | |
| Plants | Plant species from which the family is known | |
| Viruses | Viruses from which the family is known | |
| Bacteria | Bacteria from which the family is known | |
| Archaezoa | Archaezoa from which the family is known | |
| Archaea | Archaea from which the family is known | |
| Fungi | Fungi from which the family is known | |
| Protozoa | Protozoa from which the family is known | |
| Clan level | ||
| VAR1 is the standard MEROPS identifier for the clan of peptidases or inhibitors. Examples: AA, IM, MA(E) |
Summary or default | Summary for the clan |
| Alignment | Summary sequence alignment | |
| Structure | 2D structures for the clan | |
| Literature | Literature for the clan | |
| General pages | ||
| Main (default) | default | Peptidases title page |
| iMain | default | Inhibitors title page |
| New | default | What's New? |
| Search | default | Menu of Searches for peptidases |
| iSearch | default | Menu of Searches for inhibitors |
| Comm | default | Community page |
| Org | default | Organism/peptidases index |
| e.g. sp000033 (MEROPS identifier for an organism) | Organism/peptidases summary page | |
| iOrg | default | Organism/inhibitors index |
| e.g. sp000033 (MEROPS identifier for an organism) | Organism/inhibitors summary page | |
| Blast | default | BLAST menu page |
| about | e.g. about_0 up to about_13 | Page of the About documentation |
| Est | default | List of EST library indexes |
| [hs/mm]\d* (i.e. hs or mm followed by EMBL identifier for an EST library) | Peptidase EST data for the given library | |
| substrate | e.g. P05067 (UniProt accession) | Show known cleavages of this protein substrate |
| Index | PepName | Index of peptidases by name |
| pep[a-z] | Peptidases name index, page A...Z | |
| iNam | Index of inhibitors by name | |
| inh[a-z] | Inhibitors name index, page A...Z | |
| smi | Index of small molecule inhibitors by name | |
| gene | Index of peptidases by gene name | |
| igene | Index of inhibitors by gene name | |
| aspi, cysi, meti, seri, or txui | Index of aspartic, cysteine, metallo, serine, or threonine, unknown and compound peptidase | |
| indx | Index of inhibitors by identifier | |
| Org | Index of organisms and their peptidases | |
| iOrg | Index of organisms and their inhibitors | |
| FamId | Index of peptidase families by identifier | |
| iFamId | Index of inhibitor families by identifier | |
| ClanId | Index of peptidase clans by identifier | |
| iClanId | Index of inhibitor clans by identifier | |
| kingdist | Distribution of peptidase clans and families among kingdoms of organisms | |
| ikingdist | Distribution of inhibitor clans and families among kingdoms of organisms | |
| trail | Audit trail for changed identifiers | |
| newcode | New peptidase/inhibitor identifiers | |
| pepstat | Statistics for peptidases | |
| istat | Statistics for inhibitors | |
| peplist | Peptidase List | |
| pepimg | Index of molecular images for peptidases | |
| iimg | Index of molecular images for inhibitors | |
| esti | List of EST library indexes | |
| unseq | Peptidases not allocated to families | |
| [hs/mm]estln | Index of human/mouse EST libraries by library number | |
| [hs/mm]estts | Index of human/mouse EST libraries by tissue | |
| [hs/mm]estdv | Index of human/mouse EST libraries by developmental stage | |
| [hs/mm]estdi | Index of human/mouse EST libraries by disease state | |
DAS server
A distribution annotation system (DAS) server has been set up to allow a user to extract data directly from the MEROPS MySQL database for inclusion in his or her own Internet service. By including a UniProt accession or EMBL or GenBank ProtID in the URL, data relating to that sequence stored in our collection will be returned. For a peptidase or protein inhibitor, this will include the MEROPS identifier, family and clan, the residue range of the peptidase or inhibitor unit, active site residues for a peptidase (and metal ligands for a metallopeptidase), the amino acid sequence and a link to MEROPS for each feature. For a protein substrate, the position of the P1 residue in each cleavage site and the MEROPS identifier of the peptidase responsible are returned. Exanmples of URLs are:
| Features for human cathepsin B | http://das.sanger.ac.uk/das/merops/features?segment=P07858 |
| Sequence for human cathepsin B | http://das.sanger.ac.uk/das/merops/sequence?segment=P07858 |
| Known cleavages for human amyloid beta A4 protein precursor | http://das.sanger.ac.uk/das/merops/features?segment=P05067 |
