Non-Human Primates

Welcome to the NHP database, a specialist database for the Major Histocompatibility Complex genes of Non-Human Primates. The database includes Apes and both Old World and New World monkeys. It presently covers over 51 different primate species and is subject to quality control. Incorporated in the database are currently known and annotated (full-length, or minimal exons 2 and 3) MHC class I sequences, and (full-length, or minimal exon 2) MHC class II sequences.

Nomenclature

For allele designation the database uses the 2010 nomenclature rules described by the WHO Nomenclature Committee for Factors of the HLA System.

The alignments used have been curated by:

  • Natasja de Groot, Nel Otting and Ronald Bontrop
    Biomedical Primate Research Centre
    Lange Kleiweg 161
    RIJSWIJK
    The Netherlands
    Tel: +31 15 284 2699
    Fax: +31 15 284 3999
    Email: ipdmhc.nhp@bprc.nl
    URL: http://www.bprc.nl/

Tools

Alleles per species per class

Roll over the graph to view the number of alleles per species

References

Please cite the IPD-MHC NHP database whenever you publish your sequences. When citing the database you can use the following articles.

  • Maccari G, Robinson J, Ballingall K, Guethlein LA, Grimholt U, Kaufman J, Ho CS, De Groot NG, Flicek P, Bontrop RE, Hammond JA and Marsh SGE IPD-MHC 2.0: an improved inter-species database for the study of the major histocompatibility complex. Nucleic Acids Res. (2017), 45: D860–D864
  • Robinson J, Waller MJ, Stoehr P, Marsh SGE IPD-the Immuno Polymorphism Database Nucleic Acids Research (2013) 41:D1222-7
  • de Groot NG, Otting N, Robinson J, Blancher A, Lafont BAP, Marsh SGE, O'Connor DH, Shiina T, Walter L, Watkins DI, Bontrop RE Nomenclature report on the major histocompatibility complex genes and alleles of Great Ape, Old and New World monkey species Immunogenetics (2012), 64 (8): 615-631

Group curator

Miss. Natasja de Groot - degroot [at] bprc.nl

Biomedical Primate Research Centre, Department of Comparitive Genetics and Refinement, The Netherlands

Organisms

Below a list of organisms belonging to the Non-Human Primates group. The official designations are assigned by the Comparative MHC Nomenclature Committee as established by the International Society for Animal Genetics (ISAG) who are affiliated to the International Union of Immunological Societies (IUIS) - Veterinary Immunology Committee (VIC). When available, organism aliases are written in parentheses.

Species Common Name Class I Class II
Gorilla beringei (Gobe) eastern gorilla B C OKO
Gorilla gorilla (Gogo) Gorilla A B C E G H OKO DMB DPA1 DPB1 DQA1 DQA2 DQB1 DQB2 DRB DRB1 DRB3 DRB5 DRB6
Pan paniscus (Papa) Bonobo A B C G H DMB DPB1 DRB1 DRB6
Pan troglodytes (Patr) Common Chimpanzee A AL B C E F G H DMB DOB DPA1 DPB1 DQA1 DQA2 DQB1 DQB2 DRA DRB DRB1 DRB3 DRB4 DRB5 DRB6 DRB7
Pongo abelii (Poab) Sumatran Orangutan A B C
Pongo pygmaeus (Popy) Bornean Orangutan A Ap B C E H DMB DPA1 DPB1 DQA1 DQA2 DQB1 DQB2 DRB5 DRB6
Hylobates lar (Hyla) Lar Gibbon A B DQA1 DQA2 DQB1 DQB2
Hylobates moloch (Hymo) Silvery Javan Gibbon DRB DRB1
Cercocebus atys (Ceat) Sooty Mangabey A1 Aw1 Aw2 B E F I
Cercopithecus mitis (Cemi) Blue Monkey A B DQA1
Cercopithecus neglectus (Cene) De Brazza's monkey DQA1
Chlorocebus aethiops (Chae) Grivet A B G DQA1 DQB1 DRB DRB1 DRB5 DRB6
Chlorocebus pygerythrus (Chpy) vervet monkey A B
Chlorocebus sabaeus (Chsa) Green Monkey A AG B E DPA1 DPB1 DQA1 DQB1 DRA DRB DRB1 DRB5
Colobus guereza (Cogu) Mantled Guereza DQA1
Lophocebus aterrimus (Loat) Black Crested Mangabey DQA1
Macaca arctoides (Maar) Stump-tailed Macaque A1 B I DPA1 DQA1 DQB1 DRB1 DRB5
Macaca assamensis (Maas) Assam Macaque A1 B I
Macaca fascicularis (Mafa) Crab-eating Macaque A1 A2 A3 A4 A5 A6 A8 AG B B11L B16 B17 B20 B21 E F G I DMA DMB DOA DOB DPA1 DPB1 DQA1 DQB1 DRA DRB DRB1 DRB3 DRB4 DRB5 DRB6
Macaca fuscata (Mafu) Japanese Macaque DRB DRB1 DRB3
Mandrillus leucophaeus (Male) Drill DRB1
Macaca leonina (Malo) Northern Pig-tailed Macaque A1 A2 A3 B I DRB1
Macaca mulatta (Mamu) Rhesus Monkey A1 A2 A3 A4 A5 A6 A7 AG B B11L B16 B17 B20 E F G I DMA DMB DPA1 DPB1 DQA1 DQB1 DRA DRB DRB1 DRB3 DRB4 DRB5 DRB6
Macaca nemestrina (Mane) Southern Pig-tailed Macaque A1 A2 A3 A4 A5 A6 A7 AG B B12 B16 B17 B20 E I DPA1 DPB1 DQA1 DQB1 DRA DRB DRB1 DRB3 DRB5 DRB6
Macaca silenus (Masi) Lion-tailed Macaque DRB DRB1 DRB4
Mandrillus sphinx (Masp) Mandrill DRB DRB1 DRB3 DRB5 DRB6
Macaca thibetana (Math) Milne Edward's Macaque A1 A2 B I DPB1 DQB1
Papio anubis (Paan) Olive Baboon A AG B DPA1 DPB1 DQA1 DQB1 DRA DRB DRB1 DRB3 DRB5 DRB6
Papio cynocephalus (Pacy) Yellow Baboon A B E DQA1
Papio hamadryas (Paha) Hamadryas Baboon A B DPA1 DQA1 DQB1 DRB1
Papio papio (Papp) Guinea Baboon DQA1
Papio ursinus (Paur) Chacma Baboon DRB DRB1 DRB5 DRB6
Semnopithecus entellus (Seen) Northern Plains Gray Langur DPB1
Theropithecus gelada (Thge) Gelada DQA1
Aotus azarai (Aoaz) Azara's Night Monkey DRB DRB3
Aotus nancymaae (Aona) Nancy Ma's Night Monkey DPB1 DQA1 DQB1 DQB2 DRB DRB1 DRB3
Aotus nigriceps (Aoni) Black-headed Night Monkey DRB DRB1 DRB3
Aotus trivirgatus (Aotr) Three-striped Night Monkey E G PS2 DQB2 DRB DRB1 DRB3
Aotus vociferans (Aovo) Spix's Night Monkey DRB DRB1 DRB3
Ateles belzebuth (Atbe) White-fronted Spider Monkey B E G DRB
Ateles fusciceps (Atfu) Black-headed Spider Monkey B E G
Callithrix jacchus (Caja) Common Marmoset B B1 B2 B3 B4 B5 B6 B7 B8 B9 E F F1Ps F2Ps F3Ps F5Ps G G10Ps G11Ps G13Ps G14Ps G2Ps G4Ps G5Ps G6Ps G8Ps G9Ps PS2 DQA1 DQB1 DQB2 DRB DRB1
Callicebus moloch (Camo) Red-bellied Titi DRB DRB1 DRB11 DRB3
Callithrix pygmaea (Capy) Pygmy Marmoset DRB DRB1
Cebus apella (Ceap) Tufted Capuchin DRB
Leontopithecus rosalia (Lero) Golden Lion Tamarin G
Pithecia pithecia (Pipi) White-faced Saki B E G DRB DRB3
Saguinus fuscicollis (Safu) Brown-mantled Tamarin G PS1 PS2
Saguinus geoffroyi (Sage) Geoffroy's Tamarin PS1 PS2
Saguinus labiatus (Sala) White-lipped Tamarin G DRB DRB1
Saguinus mystax (Samy) Moustached Tamarin PS1 PS2
Saguinus oedipus (Saoe) Cottontop Tamarin E F G N1 N3 N4 PS1 DPB1 DQA1 DQB1 DQB2 DRB DRB1 DRB11 DRB3 DRB5
Saimiri sciureus (Sasc) Cottontop Tamarin G DPA1 DRB