Bovins

Welcome to the IPD-MHC BoLA page. This is intended to be the definitive source of information on the bovine major histocompatibility complex - its genes, proteins and polymorphism. The BoLA nomenclature committee is a standing committee of the International Society for Animal Genetics. Its purpose is to collate data on the Bovine Leucocyte Antigens (BoLA) and provide a forum for the analysis and nomenclature of polymorphisms in the genes and proteins of the bovine MHC. The information gathered here is based in part on the BoLA workshop reports, produced when the committee was active, which are published in Animal Genetics and the European Journal of Immunogenetics. The workshop report data are reproduced with the permission of the publishers Blackwell Science, and other text on the site is used with the permission of CRC Press. The committee acknowledges their cooperation in making this site possible.

Alleles

List all Bovins alleles

Species

Species belonging to the Bovins group

Align

Multi locus inter- and intra- species alignment

Haplotypes

List Bovins haplotypes

Nomenclature

We have listed all the currently known and validated alleles, as nucleotide sequence alignments, for cattle class I and class II loci in the following tables. The most recent nomenclature is used where possible, and tables of previous equivalents are given. Accession numbers and references for published sequences are listed.

In 2012 a refinement of the previous nomenclature was proposed, naming nearly 100 known classical class I sequences in a single series, by segregating these alleles into six groups (Hammond et al., 2012).

BoLA-DRB3

385

Class II

BoLA-DQB

91

Class II

BoLA-DQA

76

Class II

BoLA-2

48

Class I

BoLA-3

44

Class I

Bubu-DQA

39

Class II

Bofr-DQB1

36

Class II

BoLA-NC1

23

Class I

BoLA-1

18

Class I

Bogr-DQB

18

Class II

Above are listed the most populated genes within the Bovins group. To list all the genes within the BoLA taxonomic group, please visit the species page.

Search BoLA alleles

Group curator

Prof. John Hammond - john.hammond [at] pirbright.ac.uk

The Pirbright Institute, Immunogenetics, United Kingdom

References

The first volume of Nucleic Acids Research in 2010 is dedicated to factual databases in the field of molecular biology and contains the following paper on IPD.

  • Maccari G, Robinson J, Ballingall K, Guethlein LA, Grimholt U, Kaufman J, Ho CS, De Groot NG, Flicek P, Bontrop RE, Hammond JA and Marsh SGE IPD-MHC 2.0: an improved inter-species database for the study of the major histocompatibility complex. Nucleic Acids Res. (2017), 45: D860–D864
  • Robinson J, Mistry K, McWilliam H, Lopez R, Marsh SGE. IPD-the Immuno Polymorphism Database. Nucleic Acids Res. (2010), 38:D863-9 Full Text available from Nucleic Acids Research
  • Hammond JA, Marsh SGE, Robinson J, Davies CJ, Stear MJ, Ellis SA. Cattle MHC nomenclature: is it possible to assign sequences to discrete class I genes? Immunogenetics (2012) 64:475-480.