Fully Sequenced KIR Haplotypes

The graphic below illustrates the gene compostion of a number of fully sequenced KIR haplotypes. Where possible the alleles sequenced at the genes are also listed. The allele designations will be displayed if you hover the mouse over the gene of interest. Clicking on the gene of interest will also take you to the entry page for the allele listed. Some genes are only partially sequenced and for these an allele designation is not provided. Clicking on the Source name will take you to the Cell Directory entry for the Haplotype source. The nomenclature for KIR haplotypes has not yet been implemented and the entry in the Hap. column uses a local designation for describing the haplotypes listed.

Source Haplotype 3DL32DS22DL2/32DL5B2DS3/52DP12DL13DP12DL43DL1/S12DL5A2DS3/52DS12DS43DL2 Sequence
                     
ABC08 A 3DL3*0090102Not present2DL3*0010102Not presentNot present2DP1*00201032DL1*00302033DP1*00302022DL4*00103033DL1*0250101Not presentNot presentNot present2DS4*00101043DL2 partial sequence View
G085 A 3DL3*0090101Not present2DL3*0010104Not presentNot present2DP1*00201032DL1*00302063DP1*00302042DL4*0113DL1*0050101Not presentNot presentNot present2DS4*0103DL2*0010302 View
RSH A 3DL3*0090101Not present2DL3*0010107Not presentNot present2DP1*00201052DL1*00302093DP1*0082DL4*00103073DL1*01701Not presentNot presentNot present2DS4*00101083DL2*023 View
FH06 A 3DL3*0090103Not present2DL3*0010103Not presentNot present2DP1*00201102DL1*00302043DP1*00302022DL4*00103053DL1*0080101Not presentNot presentNot present2DS4*00301043DL2*00901 View
UV5HL9-5B A 3DL3*0020101Not present2DL3*0010111Not presentNot present2DP1*00201012DL1*00302013DP1*00302012DL4*00801013DL1*0010101Not presentNot presentNot present2DS4*00301013DL2*0010101 View
LUCE A 3DL3*0020601Not present2DL3*0010106Not presentNot present2DP1*0082DL1*00302083DP1*003032DL4*00102023DL1*0150201Not presentNot presentNot present2DS4*00101013DL2*0020104 View
FH13 A 3DL3*012Not present2DL3*0010109Not presentNot present2DP1*00201092DL1*00302103DP1*01001012DL4*001033DL1*0150101Not presentNot presentNot present2DS4*00101013DL2*01301 View
G248 A 3DL3*048Not present2DL3*0010110Not presentNot present2DP1*00201082DL1*00302043DP1*00302062DL4*00102013DL1*0290102Not presentNot presentNot present2DS4*00101023DL2*0020106 View
T7526 A 3DL3*00802Not present2DL3*0010108Not presentNot present2DP1*00201062DL1*00302053DP1*00302022DL4*00102013DL1*0150203Not presentNot presentNot present2DS4*00101073DL2*0020105 View
FH05 A 3DL3*00101Not present2DL3*0020102Not presentNot present2DP1*0042DL1*00201023DP1*0062DL4*00103043DL1*062Not presentNot presentNot present2DS4*00101063DL2*00903 View
FH15 A 3DL3*019Not present2DL3*0020103Not presentNot present2DP1*00301022DL1*00201033DP1*00601012DL4*00802043DL1*0040101Not presentNot presentNot present2DS4*00601023DL2*00501 View
FH08 A 3DL3*005Not present2DL3*006Not presentNot present2DP1*0072DL1*003033DP1*00302032DL4*00103063DL1*0150202Not presentNot presentNot present2DS4*00101053DL2*0020102 View
ABC08 AB 3DL3*0090102Not present2DL3*0010102Not presentNot present2DP1*00201072DL1*0253DP1*00302052DL4*00103083DS1*0142DL5A by typing2DS3/5 partial sequence2DS1 partial sequenceNot present3DL2*056 View
GRC212 AB 3DL3*01001Not present2DL3*0010105Not presentNot present2DP1*00201042DL1*00302073DP1*00302022DL4*00501013DS1*01301022DL5A*00501032DS3*00201012DS1*0020105Not present3DL2*0070102 View
G085 BA1 3DL3*01402012DS2*00101022DL2*0010103Not presentNot presentNot presentNot present3DP1*0012DL4*006023DL1*0070101Not presentNot presentNot present2DS4*00401013DL2*008 View
FH06 BA1 3DL3*0362DS2*00101062DL2*0030104Not presentNot presentNot presentNot present3DP1*00901022DL4*00801053DL1*0010102Not presentNot presentNot present2DS4*00301033DL2*0010102 View
GRC212 BA1 3DL3*00402012DS2*00101072DL2*0030105Not presentNot presentNot presentNot present3DP1*0072DL4*00102013DL1*0290101Not presentNot presentNot present2DS4*00101093DL2*0020103 View
FH08 BA2X 3DL3 partial sequenceNot present2DL3*0102DL5B*006012DS5*0102DP1*0062DL1*0103DP1*009022DL4*00802033DL1*063Not presentNot presentNot present2DS4*00601013DL2*00202 View
FH13 BA2 3DL3*01402032DS2*00101112DL2*00101052DL5B*00801012DS5*0072DP1*0102DL1*00401023DP1*00304022DL4*011013DL1*0050102Not presentNot presentNot present2DS4*0103DL2*01001 View
RSH BA2 3DL3*00402022DS2*00101092DL2*00101042DL5B*0042DS5*00601012DP1*0092DL1*012013DP1*00304012DL4*0113DL1*0050102Not presentNot presentNot present2DS4*0103DL2*01001 partial sequence View
G248 BA2 3DL3*00301042DS2*00101122DL2*00101072DL5B*00201072DS3*00103022DP1*00102032DL1*0073DP1*00301012DL4*006023DL1*0070102Not presentNot presentNot present2DS4*00401023DL2*008 partial sequence View
LUCE Bdel 3DL3*01402022DS2*00101082DL2*0030106Not presentNot presentNot presentNot present3DP1*00901012DL4*005013DS1*01301012DL5A*00101032DS5*00201042DS1*0020103Not present3DL2*018 View
RPCI-1   3DL3*00301012DS2*00101012DL2*0030101Not presentNot presentNot presentNot present3DP1*0022DL4*00501013DS1*01301012DL5A*00101012DS5*00201012DS1*0020101Not present3DL2*006/007 View
T7526 Bdel 3DL3*008012DS2*00101102DL2*0030107Not presentNot presentNot presentNot present3DP1*00901032DL4*00501013DS1*01301032DL5A*00501042DS3*00201022DS1*0020106Not present3DL2*0070102 View
FH05 B 3DL3*00301032DS2*00101052DL2*00101022DL5B*00201012DS3*00103012DP1*00102012DL1*00401013DP1*00301022DL4*005013DS1*01301012DL5A*00501012DS3*00201012DS1*0020104Not present3DL2*0070103 View
FH15 B 3DL3*00301 p2DS2*00101052DL2*00101062DL5B*00201072DS3*00103012DP1*00102022DL1*00401013DP1*00301022DL4*005013DS1*01301012DL5A*00501012DS3*00201032DS1*0020104Not present3DL2*0070103 View
WT47 B 3DL3*00301022DS2*00101022DL2*00101012DL5B*00201032DS3*00103012DP1*00102012DL1*00401013DP1*00301012DL4*00501013DS1*01301012DL5A*00101022DS5*00201022DS1*0020102Not present3DL2*0070101 View
                     
Source Haplotype 3DL32DS22DL2/32DL5B2DS3/52DP12DL13DP12DL43DL1/S12DL5A2DS3/52DS12DS43DL2 Sequence
                     
Key   Framework gene
(can be activating,
inhibiting
or a pseudogene)		?Inhibitory gene?Activating gene?PseudogeneNot presentGene not present  

References

All references are linked to the PubMed abstract where possible.

  1. Hsu KC, Chida S, Geraghty DE, Dupont B. The killer cell immunoglobulin-like receptor (KIR) genomic region: gene-order, haplotypes and allelic polymorphism. Immunological Review (2002) 190:40-52 (Abstract)
  2. Pyo CW, Guethlein LA, Vu Q, Wang R, Abi-Rached L, Norman, PJ, Marsh SGE, Miller JS, Parham P, Geraghty DE. Different patterns of evolution in the centromeric and telomeric regions of group a and B haplotypes of the human killer cell Ig-like receptor locus. PLoS One (2010) 5:e15115 (Abstract)