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CHEBI:9513 - thalidomide
| ChEBI ID | CHEBI:9513 |
| ChEBI Name | thalidomide |
| Stars | |
| Definition | A racemate comprising equimolar amounts of R- and S-thalidomide. |
| Last Modified | 23 May 2019 |
| Formula | C13H10N2O4 |
| Net Charge | 0 |
| Average Mass | 258.233 |
| Monoisotopic Mass | 258.06406 |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | leprostatic drug A substance that suppresses Mycobacterium leprae, ameliorates the clinical manifestations of leprosy, and/or reduces the incidence and severity of leprous reactions. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. teratogenic agent A role played by a chemical compound in biological systems with adverse consequences in embryo developments, leading to birth defects, embryo death or altered development, growth retardation and functional defect. |
| Applications: | anti-inflammatory drug A substance that reduces or suppresses inflammation. angiogenesis inhibitor An agent and endogenous substances that antagonize or inhibit the development of new blood vessels. leprostatic drug A substance that suppresses Mycobacterium leprae, ameliorates the clinical manifestations of leprosy, and/or reduces the incidence and severity of leprous reactions. antiemetic A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. anticonvulsant A drug used to prevent seizures or reduce their severity. sedative A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| thalidomide (CHEBI:9513) has part (R)-thalidomide (CHEBI:61917) |
| thalidomide (CHEBI:9513) has part (S)-thalidomide (CHEBI:61918) |
| thalidomide (CHEBI:9513) has role angiogenesis inhibitor (CHEBI:48422) |
| thalidomide (CHEBI:9513) has role anti-inflammatory drug (CHEBI:35472) |
| thalidomide (CHEBI:9513) has role anticonvulsant (CHEBI:35623) |
| thalidomide (CHEBI:9513) has role antiemetic (CHEBI:50919) |
| thalidomide (CHEBI:9513) has role antineoplastic agent (CHEBI:35610) |
| thalidomide (CHEBI:9513) has role immunosuppressive agent (CHEBI:35705) |
| thalidomide (CHEBI:9513) has role leprostatic drug (CHEBI:35816) |
| thalidomide (CHEBI:9513) has role sedative (CHEBI:35717) |
| thalidomide (CHEBI:9513) has role teratogenic agent (CHEBI:50905) |
| thalidomide (CHEBI:9513) is a racemate (CHEBI:60911) |
| Incoming Relation(s) |
| 5-(2,2-diferuloylethen-1-yl)thalidomide (CHEBI:74775) has functional parent thalidomide (CHEBI:9513) |
| 5-[2-(feruloyl)ethen-1-yl]thalidomide (CHEBI:74774) has functional parent thalidomide (CHEBI:9513) |
| pomalidomide (CHEBI:72690) has functional parent thalidomide (CHEBI:9513) |
| IUPAC Name |
|---|
| rac-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione |
| INNs | Source |
|---|---|
| talidomida | ChemIDplus |
| thalidomide | ChemIDplus |
| thalidomidum | ChemIDplus |
| Synonyms | Source |
|---|---|
| Thalidomide | KEGG COMPOUND |
| N-Phthalyl-glutaminsaeure-imid | ChemIDplus |
| N-(2,6-dioxo-3-piperidyl)phthalimide | ChemIDplus |
| N-phthaloylglutamimide | ChemIDplus |
| (±)-thalidomide | ChemIDplus |
| (±)-N-(2,6-dioxo-3-piperidyl)phthalimide | ChemIDplus |
| Brand Names | Source |
|---|---|
| Sedalis | DrugBank |
| Softenon | ChemIDplus |
| K-17 | ChemIDplus |
| Distaval | ChemIDplus |
| Talimol | ChemIDplus |
| Manual Xrefs | Databases |
|---|---|
| C07910 | KEGG COMPOUND |
| D00754 | KEGG DRUG |
| DB01041 | DrugBank |
| GB768821 | Patent |
| Thalidomide | Wikipedia |
| HMDB0015175 | HMDB |
| WO2013100657 | Patent |
| US2012142734 | Patent |
| LSM-1914 | LINCS |
| Citations |
|---|