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CHEBI:9513 - thalidomide
| ChEBI ID | CHEBI:9513 |
| ChEBI Name | thalidomide |
| Stars | |
| Definition | A racemate comprising equimolar amounts of R- and S-thalidomide. |
| Last Modified | 23 May 2019 |
| Formula | C13H10N2O4 |
| Net Charge | 0 |
| Average Mass | 258.233 |
| Monoisotopic Mass | 258.06406 |
| Wikipedia |
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| Roles Classification |
|---|
| Biological Roles: | immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. antiviral agent A substance that destroys or inhibits replication of viruses. leprostatic drug A substance that suppresses Mycobacterium leprae, ameliorates the clinical manifestations of leprosy, and/or reduces the incidence and severity of leprous reactions. teratogenic agent A role played by a chemical compound in biological systems with adverse consequences in embryo developments, leading to birth defects, embryo death or altered development, growth retardation and functional defect. anti-HIV agent An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. |
| Applications: | antiemetic A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. anti-inflammatory drug A substance that reduces or suppresses inflammation. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. antifibrotic agent Any agent which acts to reduce fibrosis. leprostatic drug A substance that suppresses Mycobacterium leprae, ameliorates the clinical manifestations of leprosy, and/or reduces the incidence and severity of leprous reactions. angiogenesis inhibitor An agent and endogenous substances that antagonize or inhibit the development of new blood vessels. antitussive An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration. anticonvulsant A drug used to prevent seizures or reduce their severity. anti-inflammatory agent Any compound that has anti-inflammatory effects. antipsoriatic A drug used to treat psoriasis. sedative A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| thalidomide (CHEBI:9513) has part (R)-thalidomide (CHEBI:61917) |
| thalidomide (CHEBI:9513) has part (S)-thalidomide (CHEBI:61918) |
| thalidomide (CHEBI:9513) has role analgesic (CHEBI:35480) |
| thalidomide (CHEBI:9513) has role angiogenesis inhibitor (CHEBI:48422) |
| thalidomide (CHEBI:9513) has role anti-HIV agent (CHEBI:64946) |
| thalidomide (CHEBI:9513) has role anti-inflammatory agent (CHEBI:67079) |
| thalidomide (CHEBI:9513) has role anti-inflammatory drug (CHEBI:35472) |
| thalidomide (CHEBI:9513) has role anticonvulsant (CHEBI:35623) |
| thalidomide (CHEBI:9513) has role antiemetic (CHEBI:50919) |
| thalidomide (CHEBI:9513) has role antifibrotic agent (CHEBI:233423) |
| thalidomide (CHEBI:9513) has role antineoplastic agent (CHEBI:35610) |
| thalidomide (CHEBI:9513) has role antipsoriatic (CHEBI:50748) |
| thalidomide (CHEBI:9513) has role antitussive (CHEBI:51177) |
| thalidomide (CHEBI:9513) has role antiviral agent (CHEBI:22587) |
| thalidomide (CHEBI:9513) has role immunosuppressive agent (CHEBI:35705) |
| thalidomide (CHEBI:9513) has role leprostatic drug (CHEBI:35816) |
| thalidomide (CHEBI:9513) has role sedative (CHEBI:35717) |
| thalidomide (CHEBI:9513) has role teratogenic agent (CHEBI:50905) |
| thalidomide (CHEBI:9513) is a racemate (CHEBI:60911) |
| Incoming Relation(s) |
| 5-(2,2-diferuloylethen-1-yl)thalidomide (CHEBI:74775) has functional parent thalidomide (CHEBI:9513) |
| 5-[2-(feruloyl)ethen-1-yl]thalidomide (CHEBI:74774) has functional parent thalidomide (CHEBI:9513) |
| pomalidomide (CHEBI:72690) has functional parent thalidomide (CHEBI:9513) |
| IUPAC Name |
|---|
| rac-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione |
| INNs | Source |
|---|---|
| talidomida | ChemIDplus |
| thalidomide | ChemIDplus |
| thalidomidum | ChemIDplus |
| Synonyms | Source |
|---|---|
| 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)isoindoline | ChemIDplus |
| 2,6-dioxo-3-phthalimidopiperidine | ChemIDplus |
| 3-phthalimidoglutarimide | ChemIDplus |
| .alpha.-phthalimidoglutarimide | ChEMBL |
| Celgene | ChEMBL |
| Contergan | ChEMBL |
| Brand Names | Source |
|---|---|
| Distaval | ChemIDplus |
| K-17 | ChemIDplus |
| Kevadon | ChEMBL |
| Sedalis | DrugBank |
| Softenon | ChemIDplus |
| Talidex | ChEMBL |
| Manual Xrefs | Databases |
|---|---|
| C07910 | KEGG COMPOUND |
| D00754 | KEGG DRUG |
| DB01041 | DrugBank |
| GB768821 | Patent |
| HMDB0015175 | HMDB |
| LSM-1914 | LINCS |
| Thalidomide | Wikipedia |
| US2012142734 | Patent |
| WO2013100657 | Patent |
| Citations |
|---|