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CHEBI:72690 - pomalidomide

ChEBI IDCHEBI:72690
ChEBI Namepomalidomide
Stars
DefinitionAn aromatic amine that is thalidomide substituted at position 4 on the isoindole ring system by an amino group. Used for the treatment of multiple myeloma in patients who failed to respond to previous therapies.
Last Modified22 February 2017
SubmitterSteve
DownloadsMolfile
FormulaC13H11N3O4
Net Charge0
Average Mass273.248
Monoisotopic Mass273.07496
SMILESNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O
InChIInChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)
InChIKeyUVSMNLNDYGZFPF-UHFFFAOYSA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Role:
immunomodulator  Biologically active substance whose activity affects or plays a role in the functioning of the immune system.
Applications:
immunomodulator  Biologically active substance whose activity affects or plays a role in the functioning of the immune system.
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
angiogenesis inhibitor  An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.
ChEBI Ontology
Outgoing Relation(s)
pomalidomide (CHEBI:72690) has functional parent thalidomide (CHEBI:9513)
pomalidomide (CHEBI:72690) has role angiogenesis inhibitor (CHEBI:48422)
pomalidomide (CHEBI:72690) has role antineoplastic agent (CHEBI:35610)
pomalidomide (CHEBI:72690) has role immunomodulator (CHEBI:50846)
pomalidomide (CHEBI:72690) is a aromatic amine (CHEBI:33860)
pomalidomide (CHEBI:72690) is a dicarboximide (CHEBI:35356)
pomalidomide (CHEBI:72690) is a isoindoles (CHEBI:24897)
pomalidomide (CHEBI:72690) is a piperidones (CHEBI:48589)
IUPAC Name 
4-amino-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
INN  Source
pomalidomideKEGG DRUG
Synonyms  Source
4-AminothalidomideChemIDplus
4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dioneChemIDplus
3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimideChemIDplus
CC 4047ChemIDplus
CC-4047ChemIDplus
Brand Name  Source
PomalystChemIDplus
Manual XrefsDatabases
D08976KEGG DRUG
US2007004920Patent
US2007155791Patent
US2007048327Patent
PomalidomideWikipedia
4746DrugCentral
Registry NumbersSources
Reaxys:8340987Reaxys
CAS:19171-19-8KEGG DRUG
CAS:19171-19-8ChemIDplus
Citations