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CHEBI:72690 - pomalidomide

Default Structure
ChEBI IDCHEBI:72690
ChEBI Namepomalidomide
Stars
DefinitionAn aromatic amine that is thalidomide substituted at position 4 on the isoindole ring system by an amino group. Used for the treatment of multiple myeloma in patients who failed to respond to previous therapies.
Last Modified22 February 2017
SubmitterSteve
DownloadsMolfile
FormulaC13H11N3O4
Net Charge0
Average Mass273.248
Monoisotopic Mass273.07496
SMILESNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O
InChIInChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)
InChIKeyUVSMNLNDYGZFPF-UHFFFAOYSA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Role:
immunomodulator  Biologically active substance whose activity affects or plays a role in the functioning of the immune system.
Applications:
immunomodulator  Biologically active substance whose activity affects or plays a role in the functioning of the immune system.
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
angiogenesis inhibitor  An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.
ChEBI Ontology
Outgoing Relation(s)
pomalidomide (CHEBI:72690) has functional parent thalidomide (CHEBI:9513)
pomalidomide (CHEBI:72690) has role angiogenesis inhibitor (CHEBI:48422)
pomalidomide (CHEBI:72690) has role anti-anaemic agent (CHEBI:75835)
pomalidomide (CHEBI:72690) has role antifibrotic agent (CHEBI:233423)
pomalidomide (CHEBI:72690) has role antineoplastic agent (CHEBI:35610)
pomalidomide (CHEBI:72690) has role immunomodulator (CHEBI:50846)
pomalidomide (CHEBI:72690) is a aromatic amine (CHEBI:33860)
pomalidomide (CHEBI:72690) is a dicarboximide (CHEBI:35356)
pomalidomide (CHEBI:72690) is a isoindoles (CHEBI:24897)
pomalidomide (CHEBI:72690) is a organic molecular entity (CHEBI:50860)
pomalidomide (CHEBI:72690) is a piperidones (CHEBI:48589)
pomalidomide (CHEBI:72690) is a racemate (CHEBI:60911)
IUPAC Name 
4-amino-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
INNs  Source
pomalidomidaWHO MedNet
pomalidomideKEGG DRUG
Synonyms  Source
3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimideChemIDplus
4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dioneChemIDplus
4-AminothalidomideChemIDplus
CC 4047ChemIDplus
CC-4047ChemIDplus
IMID 3ChEMBL
Brand Names  Source
ImnovidChEMBL
Imnovid (previously pomalidomide celgene)ChEMBL
Pomalidomide accordChEMBL
Pomalidomide krkaChEMBL
Pomalidomide viatrisChEMBL
Pomalidomide zentivaChEMBL
Manual XrefsDatabases
4746DrugCentral
D08976KEGG DRUG
PomalidomideWikipedia
US2007004920Patent
US2007048327Patent
US2007155791Patent
Registry NumbersSources
Reaxys:8340987Reaxys
CAS:19171-19-8ChemIDplus
CAS:19171-19-8KEGG DRUG
Citations