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CHEBI:82671 - syrbactin
| ChEBI ID | CHEBI:82671 |
| ChEBI Name | syrbactin |
| Stars | |
| Definition | A class of azamacrocyclic natural products with a 2,7-dioxo-1,6-diazacyclododecane skeleton that includes the syringolin, glidobactin and cepafungin natural product families. In addition to their related molecular frameworks, members of the class share similar biosynthesis pathways and identical modes-of-action, being irreversible proteasome inhibitor that inhibit all three activities of eukaryotic proteasomes. |
| Last Modified | 8 August 2014 |
| Submitter | Gareth Owen |
| Roles Classification |
|---|
| Biological Role: | metabolite Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. |
| Application: | proteasome inhibitor A drug that blocks the action of proteasomes, cellular complexes that break down proteins. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| syrbactin (CHEBI:82671) has role metabolite (CHEBI:25212) |
| syrbactin (CHEBI:82671) has role proteasome inhibitor (CHEBI:52726) |
| syrbactin (CHEBI:82671) is a azamacrocycle (CHEBI:52898) |
| syrbactin (CHEBI:82671) is a lactam (CHEBI:24995) |
| Incoming Relation(s) |
| luminmycin A (CHEBI:156322) has functional parent syrbactin (CHEBI:82671) |
| syringolin A (CHEBI:80033) is a syrbactin (CHEBI:82671) |
| Synonym | Source |
|---|---|
| syrbactins | ChEBI |
| Citations |
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