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CHEBI:7640 - nortriptyline
| Formula | C19H21N |
| Net Charge | 0 |
| Average Mass | 263.384 |
| Monoisotopic Mass | 263.16740 |
| SMILES | CNCCC=C1c2ccccc2CCc2ccccc21 |
| InChI | InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-11,20H,6,12-14H2,1H3 |
| InChIKey | PHVGLTMQBUFIQQ-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
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| Chemical Role: | Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). |
| Biological Roles: | apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. adrenergic uptake inhibitor Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. |
| Applications: | analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. adrenergic uptake inhibitor Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. antispasmodic drug A drug that suppresses spasms. These are usually caused by smooth muscle contraction, especially in tubular organs. The effect is to prevent spasms of the stomach, intestine or urinary bladder. gastrointestinal drug A drug used for its effects on the gastrointestinal system, e.g. controlling gastric acidity, regulating gastrointestinal motility and water flow, and improving digestion. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. antipsoriatic A drug used to treat psoriasis. antipsychotic agent Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. anxiolytic drug Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| nortriptyline (CHEBI:7640) has functional parent amitriptyline (CHEBI:2666) |
| nortriptyline (CHEBI:7640) has parent hydride dibenzo[a,d][7]annulene (CHEBI:35642) |
| nortriptyline (CHEBI:7640) has role adrenergic uptake inhibitor (CHEBI:35640) |
| nortriptyline (CHEBI:7640) has role analgesic (CHEBI:35480) |
| nortriptyline (CHEBI:7640) has role antidepressant (CHEBI:35469) |
| nortriptyline (CHEBI:7640) has role antineoplastic agent (CHEBI:35610) |
| nortriptyline (CHEBI:7640) has role antipsoriatic (CHEBI:50748) |
| nortriptyline (CHEBI:7640) has role antipsychotic agent (CHEBI:35476) |
| nortriptyline (CHEBI:7640) has role antispasmodic drug (CHEBI:53784) |
| nortriptyline (CHEBI:7640) has role anxiolytic drug (CHEBI:35474) |
| nortriptyline (CHEBI:7640) has role apoptosis inducer (CHEBI:68495) |
| nortriptyline (CHEBI:7640) has role drug metabolite (CHEBI:49103) |
| nortriptyline (CHEBI:7640) has role gastrointestinal drug (CHEBI:55324) |
| nortriptyline (CHEBI:7640) is a organic tricyclic compound (CHEBI:51959) |
| nortriptyline (CHEBI:7640) is a secondary amine (CHEBI:32863) |
| IUPAC Name |
|---|
| 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methylpropan-1-amine |
| INNs | Source |
|---|---|
| nortriptilina | WHO MedNet |
| nortriptylina | WHO MedNet |
| nortriptyline | WHO MedNet |
| nortriptyline | WHO MedNet |
| nortriptylinum | WHO MedNet |
| Synonyms | Source |
|---|---|
| 10,11-dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-Δ5,γ-propylamine | NIST Chemistry WebBook |
| 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine | NIST Chemistry WebBook |
| Ateben | ChemIDplus |
| Avantyl | ChemIDplus |
| Aventyl | ChemIDplus |
| demethylamitriptyline | ChemIDplus |
| Brand Names | Source |
|---|---|
| Allegron | ChEMBL |
| Motipress | ChEMBL |
| Motival | ChEMBL |
| Citations |
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